Sökning: "Extracellular phosphorylation"

Visar resultat 16 - 20 av 120 avhandlingar innehållade orden Extracellular phosphorylation.

  1. 16. Role of p70 S6 kinase in the formation of tau pathologies in Alzheimer’s disease

    Författare :Wen-Lin An; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Alzheimer s disease; p70 S6 kinase; tau; protein translation; accumulation; phosphorylation;

    Sammanfattning : One of the important neuropathological features of Alzheimer's disease (AD) is the tau pathology seen as accumulation and hyperphosphorylation of this protein. Evidences showed that tau could be phosphorylated mostly at serine/threonine (S/T) residues by many kinases, including protein kinase B, glycogen synthase kinase (GSK)-3beta, extracellular signal-regulated kinase (ERK1/2), ERK1/2 kinase (MEK1/2), c-Jun Nterminal kinase (JNK), and p38. LÄS MER

  3. 17. Regulation of signal transduction in the striatum by typical and atypical antipsychotic drugs

    Författare :Kerstin Håkansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Adenosine A2A receptor; basal ganglia; cAMP-dependent protein kinase; clozapine; DARPP-32; dopamine D 2 receptor; extracellular signal-regulated protein kinases 1 and 2; extrapyramidal side effects; glutamate AMPA receptor; haloperidol; knockout mouse; phosphorylation; schizophrenia; tyrosine hydroxylase.;

    Sammanfattning : The only effective therapy for schizophrenia is based on the use of antipsychotic drugs. These substances act as dopamine D 2 receptor antagonists and can be classified as typical or atypical. Typical antipsychotics, e.g. LÄS MER

  4. 18. Bacterial virulence and adaptation mediated by two-component system signalling

    Författare :Henrik Tomenius; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Virulence; atomic force microscopy; biofilm; adaptation; two-component system; signal transduction; gene regulation; phosphorylation; BarA; UvrY;

    Sammanfattning : One of the most fundamental ways of signal perception and propagation is mediated by the bacterial two-component system (TCS). These types of systems mediate bacterial adaptation that may cause disease in a host due to expression of virulence factors. LÄS MER

  5. 19. Adhesion Dependent Signals : Cell Survival, Receptor Crosstalk and Mechanostimulation

    Författare :Anjum Riaz; Staffan Johansson; Bengt Hallberg; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Integrins; Signal transduction; Protein kinase B; Akt; PI3K; Heparanase; ROS; Mechanosignalling; Molekylär cellbiologi; Molecular Cellbiology; Biology with specialization in Molecular Cell Biology; Biologi med inriktning mot molekylär cellbiologi; Cellforskning; Cell Research;

    Sammanfattning : The integrin family of cell surface receptors is evolutionary conserved and found in all multicellular animals. In humans 8-alpha and 18-beta integrins are non-covalently associated into 24 dimers. Integrins mediate cell-extracellular matrix and cell-cell interactions and participate in cell signalling. LÄS MER

  7. 20. In vitro modelling of tau phosphorylating kinases : emphasis of Cdk5

    Författare :Anne Jämsä; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The main hallmarks of Alzheimer’s disease (AD) are extracellular deposits of betaamyloid (Aβ) and intracellular neurofibrillary tangles (NFT) composed of highly phosphorylated tau protein. Abnormal hyperphosphorylation of tau is the most deleterious step in NFT formation making the use of kinase inhibitors an attractive treatment possibility in AD. LÄS MER