Sökning: "Drug Administration Schedule"

Hittade 3 avhandlingar innehållade orden Drug Administration Schedule.

1. 1. Pharmacokinetic-Pharmacodynamic Modelling of Anticancer Drugs : Haematological Toxicity and Tumour Response in Hollow Fibres

   Författare :Lena E Friberg; Mats Karlsson; Alan Boddy; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacokinetics Pharmacotherapy; Farmakokinetik Farmakoterapi; PHARMACY; FARMACI; farmakokinetik och läkemedelsterapi; Pharmacokinetics and Drug Therapy;

   Sammanfattning : Established quantitative relationships between dose, plasma concentrations and response [pharmacokinetic-pharmacodynamic (PKPD) models] have a high potential in improving therapeutic indices of anticancer drug therapy and in increasing drug development efficiency. PKPD modelling is a helpful tool for characterising and understanding schedule dependence. LÄS MER

3. 2. Optimization of cyclophosphamide therapy based on pharmacogenetics

   Författare :Parvaneh Afsharian; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cyclophosphamide; Pharmacogenetics; Pharmacokinetics; Cytochrome P450; CYP2136; Ciprofloxacin;

   Sammanfattning : Cyclophosphamide (CPA) is one of the most broadly used anticancer agents. CPA is also a potent immunosuppressive agent that is used for the treatment of autoimmune diseases. CPA is a prodrug that is activated in liver by a 4-hydroxylation reaction catalyzed by cytochrome P450 (CYP) enzymes. LÄS MER

4. 3. Leukemia chemotherapy : experimental studies on pharmacological optimisation

   Författare :Michèle Masquelier; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Our main goal has been to identify new means to improve chemotherapy of acute leukaemia: 1. By using low-density lipoprotein (LDL) as a drug carrier to increase the selectivity of antileukemic drugs, based on high LDL uptake in acute myeloid leukemia (AML) cells. LÄS MER