Sökning: "Cyclooxygenase"

Visar resultat 21 - 25 av 116 avhandlingar innehållade ordet Cyclooxygenase.

  1. 21. Studies on expression and regulation of phospholipase A2 and cyclooxygenase 2 in gastrointestinal tissues with special reference to colorectal cancer

    Författare :Jan Dimberg; Linköpings universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : The phospholipases A2 (PLA2s) are phospholipid hydrolyzing enzymes that in mammalian cells exist in several different isoform including cytosolic PLA2 (cPLA2), group I PLA2 (PLA2-I) and group II PLA2 (PLA2-ll). PLA2 is involved in production of inflammatory mediators, membrane remodelling, digestive functions and stimulation of prolifemtion. LÄS MER

  3. 22. Integration of Tumor and Host Factors – Implications for Breast Cancer Prognosis

    Författare :Maria Simonsson; Tumörmikromiljö; []
    Nyckelord :Breast Cancer; Prognosis and survival; CYP1A2; CYP2C8; Coffee Consumption; Alcohol Consumption; Cyclooxygenase-2 COX-2 ;

    Sammanfattning : Breast cancer is the most common cancer among women worldwide, although the mortality rates have decreased in the last decades. Breast cancer is a heterogeneous disease, and treatment resistance is a significant clinical problem in spite of the overall high survival rates. LÄS MER

  4. 23. Prostanoids and colorectal cancer

    Författare :Annika Gustafsson Asting; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; colorectal cancer prostanoid receptors cyclooxygenase PGE2 transcription factors;

    Sammanfattning : Tumor disease is a main cause of death in Western countries and a most common malignancy is colorectal cancer (CRC). Growing tumors are dependent on interactions among several different cells as well as signaling pathways. LÄS MER

  5. 24. Endometrial receptivity and development of new contraceptive methods

    Författare :Lena Marions; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Mifepristone; levonorgestrel; endometrial receptivity; emergency contraception; blastocyst implantation; integrins; cyclooxygenase;

    Sammanfattning : Ovulation and endometrial development as well as contraceptive efficacy was studied after treatment with the antiprogestin mifepristone. Mechanism of action after treatment with the gestagen levonorgestrel or mifepristone in doses effective for emergency contraception was also evaluated. LÄS MER

  7. 25. The endothelin system and cardiopulmonary dysfunction in porcine endotoxin shock

    Författare :Michael Wanecek; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Endothelin; endothelin receptor antagonism; cyclooxygenase inhibition; endotoxin; sepsis; shock; pulmonary hypertension; cardiac dysfunction;

    Sammanfattning : The endothelium-derived peptide endothelin-1, acting via the endothelinA and endothelinB receptors, possesses strong vasoconstrictive properties shown to affect pulmonary and systemic circulation as well as cardiac function. During septic and endotoxin shock a marked increase in circulating plasma endothelin-1 levels is observed which is associated with morbidity, cardiac dysfunction and lung injury. LÄS MER