Sökning: "B cell repertoire"
Visar resultat 1 - 5 av 56 avhandlingar innehållade orden B cell repertoire.
1. B cell repertoire development in normal physiology and autoimmune disease
Sammanfattning : The B cell repertoire in the neonatal immune system (IS) is characterised by reactivity towards self-components, including other immunoglobulin (Ig) V-regions. These properties have been suggested to be a requirement for the development of a normal immune system. LÄS MER
2. Solute Carriers in Metabolism : Regulation of known and putative solute carriers in the central nervous system
Sammanfattning : Solute carriers (SLCs) are membrane-bound transporter proteins, important for nutrient, ion, drug and metabolite transport across membranes. A quarter of the human genome codes for membrane-bound proteins, and SLCs make up the largest group of transporter proteins. LÄS MER
3. Studies of molecular events during peripheral B cell differentiation
Sammanfattning : This thesis focuses on molecular changes occuring during terminal B cell differentiation as well as on somatic hypermutation and the generation and maintenance of B cell memory. During T cell dependent immune responses the average affinity for the eliciting antigen increases with time. LÄS MER
4. Glycan dependent Helicobacter spp. and Streptococcus oralis binding to mucins in the gastric and oral mucosal niches
Sammanfattning : Helicobacter pylori infects the stomach of half of the world’s population, while Helicobacter suis colonizes pigs and is the most common non-H. pylori Helicobacter species that also infects human stomach. Infection with Helicobacter spp. is associated with chronic gastritis, peptic ulcer disease, and gastric cancer. LÄS MER
5. Reconstitution of the B-cell repertoire following allogeneic bone marrow transplantation
Sammanfattning : Allogeneic bone marrow transplantation (BMT) is an established therapy for patients with a variety of haematological malignancies. Patients undergoing BMT often suffer from severe infections that can be partly explained by humoral immune deficiency. LÄS MER