Sökning: "Allosteric Modulators"
Visar resultat 1 - 5 av 8 avhandlingar innehållade orden Allosteric Modulators.
1. Structure-based Virtual Screening for Ligands of G Protein-coupled Receptors : Design of Allosteric and Dual-Target Modulators
Sammanfattning : G protein-coupled receptors (GPCRs) are integral membrane proteins responsible for signal transduction of extracellular stimuli into the cell. Because of their widespread distribution throughout the human body and important roles in physiological processes, GPCRs are prominent drug targets and approximately 34% of all approved drugs interact with members of this superfamily. LÄS MER
2. Free Fatty Acid Receptor 2 - A G protein coupled receptor with unique signaling properties in neutrophils
Sammanfattning : The overall aim of the PhD thesis was to determine the role of neutrophil pattern recognition receptors in the initiation and resolution of inflammatory processes. Neutrophil pattern recognition receptors such as the formyl peptide receptors (FPRs) and the short free fatty acid receptors (FFARs) belong to the family of G protein coupled receptors (GPCR). LÄS MER
3. Allosteric modulation of pentameric ligand-gated ion channels by general anesthetics
Sammanfattning : Pentameric ligand-gated ion channels (pLGICs) are key components of fast synaptic transmission and are targets of neuroactive drugs such as benzodiazepines, alcohol and muscle relaxants. Although early theories of general anesthesia suggested non-specific lipid interaction as the mechanism of anesthetic action, it has now become evident that they too bind to pLGICs. LÄS MER
4. Simulating Functional Cycles and Drug Modulation in Ligand-gated Ion Channels
Sammanfattning : Understanding the intricate motions and conformational changes that govern biological processes remains a fascinating and challenging endeavor. The research presented in this thesis aims to elucidate the dynamic processes underlying biological functions, specifically focusing on the dynamics of pentameric ligand-gated ion channels (pLGICs), which play a crucial role in signal transduction within the brain. LÄS MER
5. Elucidating the Gating Mechanism of Cys-Loop Receptors
Sammanfattning : Cys-loop receptors are membrane proteins that are key players for the fast synaptic neurotransmission. Their ion transport initiates new nerve signals after activation by small agonist molecules, but this function is also highly sensitive to allosteric modulation by a number of compounds such as anesthetics, alcohol or anti-parasitic agents. LÄS MER