Sökning: "African sleeping sickness"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden African sleeping sickness.

  1. 1. Oral eflornithine treatment of late-stage human African trypanosomiasis

    Författare :Mikael Boberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Sleeping Sickness; Neglected Tropical Diseases; Enantiomers; Nonlinear Mixed Effects Modeling; Pharmacokinetics; Pharmacodynamics;

    Sammanfattning : Human African trypanosomiasis is a fatal disease unless treated. It is a parasitic vector borne disease endemic in sub-Saharan African countries. Eflornithine is a recommended treatment for gambiense human African trypanosomiasis (g-HAT) in the later disease stage when the parasites have infected the central nervous system. LÄS MER

  3. 2. Targets and strategies for drug development against human African sleeping sickness

    Författare :Farahnaz Ranjbarian; Anders Hofer; Staffan G. Svärd; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; T. brucei thymidine kinase; T. brucei methylthioadenosine phosphorylase; FANA-A purine nucleoside analogues; essential oils;

    Sammanfattning : Trypanosoma brucei is a causative agent of African sleeping sickness. It is an extracellular parasite which circulates in the blood, lymph and eventually invades the central nervous system. LÄS MER

  4. 3. Novel treatment of African trypanosomiasis

    Författare :Suman Kumar Vodnala; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Human African Trypanosomiasis (HAT) or Sleeping Sickness is fatal if untreated. Current drugs used for the treatment of HAT have difficult treatment regimens and unacceptable toxicity related issues. LÄS MER

  5. 4. Salvage and de novo synthesis of nucleotides in Trypanosoma brucei and mammalian cells

    Författare :Artur Fijolek; Lars Thelander; Arne Holmgren; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; nucleotides; ribonucleotide reductase; Ara-A; p53R2; Trypanosoma brucei; African sleeping sickness; trypanosomiasis; CTP synthetase; adenosine kinase; acivicin; adenine arabinoside; Biochemistry; Biokemi;

    Sammanfattning : All living cells are dependent on nucleic acids for their survival. The genetic information stored in DNA is translated into functional proteins via a messenger molecule, the ribonucleic acid (RNA). Since DNA and RNA can be considered as polymers of nucleotides (NTPs), balanced pools of NTPs are crucial to nucleic acid synthesis and repair. LÄS MER

  7. 5. Parasite signalling and host responses in experimental and human African trypanosomiasis

    Författare :Maha Hamadien; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :TLTF; anti-TLTF antibodies; IFN-gamma; Human African trypanosomiasis; T b. brucei; ;

    Sammanfattning : African trypanosomiasis or sleeping sickness is a disease of tropical Africa caused by the unicellular-flagellated protozoan parasite, Trypanosoma brucei (T b.), which is transmitted by its insect vector, the tsetse fly. In humans, there are two forms of the disease: a chronic form in West and Central Africa, caused by T. b. LÄS MER