Sökning: "AT- I cardiomyocytes"

Visar resultat 1 - 5 av 23 avhandlingar innehållade orden AT- I cardiomyocytes.

  1. 1. Cardiomyocyte Cell Cycle, Renewal and Isolation

    Författare :Stuart Walsh; Stamcellscentrum (SCC); []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; binucleation; Cardiomyocytes; surface marker; troponin-T; mitosis; microarray; cell cycle; FACS;

    Sammanfattning : Heart disease results from the loss of cardiomyocytes following myocardial damage and is a leading cause of death worldwide. Stimulating the endogenous regeneration of cardiomyocytes or isolating them from in vitro culture is an attractive therapeutic strategy. LÄS MER

  3. 2. Cardiac hypertrophy : transcription patterns, hypertrophic progression and extracellular signalling

    Författare :Nina Gennebäck; Stellan Mörner; Anders Waldenström; Urban Hellman; Ali J Marian; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiac hypertrophy; HCM; gene expression; OPLS-DA; multivariate dataanalysis; cardiomyocytes; exosomes; microvesicles; Medicine; medicin;

    Sammanfattning : Background: The aim of this thesis was to study transcription patterns and extracellular signalling of the hypertrophic heart to better understand the mechanisms initiating, controlling and maintaining cardiac hypertrophy.Cardiac hypertrophy is a risk factor for cardiovascular morbidity and mortality. LÄS MER

  4. 3. Cell shape determines gene expression in cardiomyocytes

    Författare :Payam Haftbaradaran Esfahani; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The fundamental biological processes involve sensing biophysical stress, strain and forces along with conversion of these stimuli into chemical signals. These processes are linked to the atrophic and hypertrophic responses. Deficiencies in these biological processes are associated with different diseases, particularly in the circulation system. LÄS MER

  5. 4. Thyroid hormone receptor expression in cardiovascular disease and pharmacology

    Författare :Shiva Shahrara; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :TR mRNA; amiodarone; propranolol; heart rate; Quantitative RT-PCR; Western blot; Northern blot; mRNA and protein distribution; chronic valvular disease; Mated cardiomyopathy; AT- I cardiomyocytes; mouse myocardium;

    Sammanfattning : The heart is a major target organ for thyroid hormone actions. Thyroid hormone exerts effects on the myocardium, which are mediated by specific nuclear receptors. The thyroid hormone receptors (TR) are members of the steroid hormone receptor superfamily. LÄS MER

  7. 5. Molecular pharmacology of amiodarone

    Författare :Viktor Drvota; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Amiodarone; thyroid hormone receptors; B-adrenergic receptors; AT-1 cardiomyocytes; Western blot; solution hybridization; Fura-2; Langendorff heart; mouse; guinea pig;

    Sammanfattning : Amiodarone (Am) is a potent class III antiarrhythmic drug. Its use is limited due to serious side effects and it was therefore used only when other therapeutic interventions proved to be ineffective. LÄS MER