Sökning: "1H NMR"

Visar resultat 11 - 15 av 124 avhandlingar innehållade orden 1H NMR.

  1. 11. Vanadate and Peroxovanadate Complexes of Biomedical Relevance : A speciation approach with focus on diabetes

    Författare :András Gorzsás; Lage Pettersson; Carlos F. G. C. Geraldes; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Inorganic chemistry; vanadium; hydrogen peroxide; lactate; citrate; phosphate; alanyl serine; picolinic acid; speciation; formation constants; equilibrium; solution structure; potentiometry; NMR 51V; 31P; 13C; 1H ; Oorganisk kemi; Inorganic chemistry; Oorganisk kemi; oorganisk kemi; Inorganic Chemistry;

    Sammanfattning : Diabetes mellitus is one of the most threatening epidemics of modern times with rapidly increasing incidence. Vanadium and peroxovanadium compounds have been shown to exert insulin–like actions and, in contrast to insulin, are orally applicable. However, problems with side–effects and toxicity remain. LÄS MER

  3. 12. Studies of protein structure, dynamics and protein-ligand interactions using NMR spectroscopy

    Författare :Tobias Tengel; Göran Larsson; Maria Sunnerhagen; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; 19F NMR; 2S albumin; PapD; protein-ligand interaction; structure; TFE; Yersinia; YopD; allergy; amphipathic helix; Ber e 1; Brazil nut; dynamics; FimC; LcrH; NMR screening; Biophysics; Biofysik;

    Sammanfattning : In the first part of the thesis, protein-ligand interactions were investigated using the chaperone LcrH, from Yersinia as target protein. The structure of a peptide encompassing the amphipathic domain (residue 278-300) of the protein YopD from Yersinia was determined by NMR in 40% TFE. LÄS MER

  4. 13. Mass Transport Properties in Supramolecular Systems Studied by Diffusion and Relaxation NMR

    Författare :Patrik Jarvoll Dae; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NMR; T2; diffusion; hydrogel; exchange dynamics; T1; magnetic susceptibility; organosilica nanoparticles; microstructure; relaxation; supramolecular systems;

    Sammanfattning : This thesis shows how diffusion and relaxation NMR can be applied in various aspects to study mass transport in supramolecular systems. Information about these systems can be obtained, either by direct measurement of the molecules that are incorporated in a supramolecular structure, or via probe molecules, which indirectly gives information about the system. LÄS MER

  5. 14. Protein Dynamics Studied by NMR Spin Relaxation. Conformational Transitions of a Calmodulin Mutant

    Författare :Patrik Lundström; Biofysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molekylär biofysik; Molecular biophysics; spin relaxation; rotating-frame; NMR; multiple-quantum; EF-hand; chemical shift; chemical exchange; calcium binding proteins; calmodulin;

    Sammanfattning : Binding of calcium to the protein calmodulin leads to molecular reorganization that enables interaction with target peptides and activation of downstream processes. I have studied the dynamics of the calcium-loaded form of a C-terminal calmodulin mutant (E140Q-Tr2C) using NMR spin relaxation experiments. LÄS MER

  7. 15. NMR studies of metabolites and xenobiotics : From time-points to long-term metabolic regulation

    Författare :Ina Ehlers; Jürgen Schleucher; Farquhar Graham; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NMR spectroscopy; isotopomer; phospholipid; persistent organic pollutant; CO2 fertilization; photorespiration;

    Sammanfattning : Chemical species carry information in two dimensions, in their concentrations and their isotopic signatures. The concentrations of metabolites or synthetic compounds describe the composition of a chemical or biological system, while isotopic signatures describe processes in the system by their reaction pathways, regulation, and responses to external stimuli. LÄS MER