Genetic variation in genes involved in Abeta-degradation in Alzheimer disease

Detta är en avhandling från Stockholm : Karolinska Institutet, Department of Cell and Molecular Biology

Författare: Mia Blomqvist; Karolinska Institutet.; Karolinska Institutet.; [2009]

Nyckelord: MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer disease; SNPs; genotyping; association study; haplotype; linkage disequilibrium; association mapping;

Sammanfattning: Alzheimer disease (AD) is a neurodegenerative disorder that causes dementia among mainly elderly people and is increasing in prevalence in industrialized societies from 1 to 3 % in 60-65 year-olds to as much as 50 % by age 95. This disease is complex. Multiple genes are involved, and they potentially affect each other. The strongest known genetic risk factor for developing AD is the carriage of the

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