Avancerad sökning
Visar resultat 16 - 17 av 17 avhandlingar som matchar ovanstående sökkriterier.
16. Mechanisms determining efficacy of tyrosine kinase-targeting anti-cancer drugs
Sammanfattning : The expanding field of cancer research and the introduction of multiple molecular biology techniques have significantly improved cancer drug discovery, presented new drugs, including tyrosine kinase inhibitors, and thereby gave new hope to the cancer patients and their oncologists. Using this knowledge it is now becoming increasingly possible to determine outcome of malignant disease more accurately, to estimate response to specific therapies and to get closer to the ideal of personalized targeted therapy adjusted to each patient, and to the specific cancer type and its unique genetic profile. LÄS MER
17. Transcriptional gene signatures : passing the restriction point for routine clinical implementation
Sammanfattning : Uncontrolled cell growth and cell division are central to the process of tumorigenesis and a number of gene expression signatures have been developed based on genes that are involved in the cell cycle. Notably, gene expression signatures are used extensively in breast cancer research to examine the disease at a molecular level to describe tumour progression, treatment response and patients’ survival. LÄS MER
