Sökning: "urinary elimination"

Visar resultat 1 - 5 av 24 avhandlingar innehållade orden urinary elimination.

1. 1. Elimination of caffeine metabolites in man

   Författare :Nikolaos Rodopoulos; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :C8-oxidation capillary elearophoresis dimethylxanthines high-performance liquidchromatography liver cirrhosis N-acetylation N-demethylation monomethylurates monomethylxanthines;

   Sammanfattning : Plasma, saliva and urinary caffeine (CA), paraxanthine (PX), theobromine (TB), theophylline (TP) and their metabolites were, after separation into fractions by reversed-phase high-performance liquid chromatography (HPLC), quantitated by capillary electrophoresis (CE). In healthy adults, 96% of the total amount of excreted compounds derived from CA were dimethylxanthines (DMXs) and metabolites, the remainder 4% being nonmetabolized CA and its non-demethylated urate. LÄS MER

3. 2. Urinary and faecal incontinence among older women and men in relation to other health complaints, quality of life and dependency

   Författare :Karin Stenzelius; Institutionen för hälsovetenskaper; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Urinary incontinence; Aged 75 and over; Health complaints; Gerontologi; Gerontology; Faecal incontinence;

   Sammanfattning : Aim: The aim of this thesis was to investigate type, degree and patterns of health complaints, need for help and health-related quality of life across gender among persons aged 75?105 as well as to identify how patterns of health complaints, gender, age and socio-economic factors related to need for help with daily activities and quality of life (Paper I). The aim was also to investigate the prevalence of self-reported symptoms of urinary, faecal and double incontinence among men and women aged 75 and above, and to identify how other health complaints and quality of life relate to incontinence symptoms (Paper II). LÄS MER

4. 3. On CD4+ T Lymphocytes in Solid Tumours

   Författare :Per Marits; Ola Winqvist; Magnus Thörn; Alex Karlsson-Parra; Uppsala universitet; []
   Nyckelord :Molecular medicine; Tumour immunology; T lymphocytes; sentinel node detection; colon cancer; urinary bladder cancer; adoptive immunotherapy; Molekylärmedicin;

   Sammanfattning : This thesis deals with recognition and elimination of tumours by T lymphocytes and their use in adoptive immunotherapy.The first tumour-draining lymph node; the sentinel node, is identified by peritumoural injection of a tracer. This is the hypothesised location for the activation of tumour-reactive lymphocytes. LÄS MER

5. 4. The effect of anaesthesia and adrenergic therapy on the distribution and elimination of a crystalloid solution studied by volume kinetic analysis

   Författare :Carl-Arne Ewaldsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Intravenous fluid therapy is a mandatory treasure during anaesthesia and surgery. It is sometimes combined with adrenergic therapy to maintain haemodynamic stability. It is of great importance to know how the body handles the distribution of fluid in these circumstances in order to minimize the risk of fluid overload. LÄS MER

7. 5. Consequences of CYP2D6 polymorphism for the disposition and dynamics of tolterodine : a novel drug in the treatment of urinary bladder overactivity

   Författare :Niclas Brynne; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :active metabolite; CYP2D6; CYP3A4; disposition; drug interaction; fluoxetine; ketoconazole; metabolic ratio; pharmacokinetics; tolterodine;

   Sammanfattning : The pharmacokinetics and pharmacological effects of tolterodine were studied in man following administration of increasing oral and intravenous single-doses. The influence of metabolic phenotype in extensive and poor metabolizers of debrisoquine was determined. LÄS MER