Sökning: "total synthesis"

Visar resultat 16 - 20 av 288 avhandlingar innehållade orden total synthesis.

  1. 16. Biosynthetic and synthetic studies of the fungal metabolite galiellalactone

    Författare :Martin H Johansson; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biotechnology; Bioteknik; Organisk kemi; Organic chemistry; enzyme; mycelium; intramolecular Diels-Alder reaction; Diels-Alderase; asymmetric synthesis; biosynthesis; total synthesis; STAT3 inhibition; galiellalactone; fungal metabolite;

    Sammanfattning : Galiellalactone is a fungal metabolite found in the basidiomycetes Galiella rufa and the unidentified strain A111-95. It has been shown to possess promising activities as an inhibitor of the IL-6 mediated STAT3 signaling in HepG2 cells. LÄS MER

  3. 17. Synthesis of organobromines as a tool for their characterisation and environmental occurrence assessment

    Författare :Andreas Rydén; Göran Marsh; Vladimir Nikiforov; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Polybrominated diphenyl ethers; Brominated diphenyliodoniums salts; PBDEs; OH-PBDEs; MeO-PBDEs; Synthesis; Analysis; Abbreviations; Metabolites; Marine natural products; E-waste; Brominated flameretardants; miljökemi; Environmental Chemistry;

    Sammanfattning : Polybrominated diphenyl ethers (PBDEs) have been intensively used as flame retardants (FRs) and have become ubiquitous environmental pollutants. PBDEs form hydroxylated PBDEs (OH-PBDEs) as metabolites. Further, some OH-PBDEs and methoxy-PBDEs (MeO-PBDEs) are natural products. LÄS MER

  4. 18. Synthesis of Novel Polyhydroxyl Surfactants. Influence of the Relative Stereochemistry on Surfactant Properties

    Författare :Kristina Neimert-Andersson; KTH; []
    Nyckelord :Polyhydroxyl surfactants; Sugar surfactants; Stereoselective; Synthesis; Dihydroxylation; Langmuir monolayers; Chiral discrimination;

    Sammanfattning : This thesis deals with the synthesis and characterization ofnovel polyhydroxyl surfactants. The first part describes thesynthesis of a number of stereoisomers of a polyhydroxylsurfactant, and the second part concerns surface chemicalcharacterization. LÄS MER

  5. 19. An Organic Chemistry Odyssey : Imaging Mass Spectrometry in Neurotherapeutics, Asymmetric Methodology Development and Natural Product Synthesis

    Författare :Marvin Villacrez; Kemisk biologi med inriktning mot läkemedelsutveckling; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Masspektrometri; totalsyntes; avbildande massspektrometri; MALDI avbildande massspektrometri; asymmetrisk syntes; farmakokinetik; dynamisk kinetisk resolution; Aasymetrisk överföringshydrogenering; klozapin; Läkemedelsmetabolism; läkemedelsdistribution; aminoalkoholer; Aspidophylline A; mass spectromery; Imaging mass spectrometry; Total synthesis; Dynamic kinetic resolution; asymmetric transfer hydrogenation; Aspidophylline A; Drug distribution; Drug metabolism; Drug Metabolism and Mass Spectrometry Imaging; MALDI mass spectrometry imaging; clozapine; amino alcohols; pharmacokinetics;

    Sammanfattning : The development of imaging technologies and brain models is crucial for advancements in neurotherapeutic drug discovery and development. They assume a critical role in evaluating essential parameters such as drug blood-brain barrier (BBB) permeation, distribution, and metabolism, all of which are vital for the development of safe and effective medications. LÄS MER

  7. 20. Amino Aacohols : stereoselective synthesis and applications in diversity-oriented synthesis

    Författare :Staffan Torssell; Peter Somfai; KTH; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; amino alcohol; carbenoid; carbonyl ylide; cross-metathesis; diastereoselective; 1; 3-dipolar cycloaddition; sphingosine; Organisk kemi; Organic chemistry; Organisk kemi;

    Sammanfattning : This thesis is divided into three separate parts with amino alcohols as the common feature. The first part describes the development of a novel three-component approach to the synthesis of α-hydroxy-β-amino esters. LÄS MER