Sökning: "therapy failure"

Visar resultat 1 - 5 av 313 avhandlingar innehållade orden therapy failure.

  1. 1. Heart failure : biomarker effect and influence on quality of life

    Författare :Patric Karlström; Urban Alehagen; Mikael Dellborg; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heart failure; Biomarker; B-type natriuretic peptide; Heart failure treatment; B-type Natriuretic Peptide guided heart failure treatment; Responders; Health-related quality of life; Heart failure duration; Outcomes;

    Sammanfattning : Background and aims: Heart failure (HF) is a life threatening condition and optimal handling is necessary to reduce risk of therapy failure. The aims of this thesis were: (Paper I) to examine whether BNP (B-type natriuretic peptide)-guided HF treatment improves morbidity and mortality when compared with HF therapy implemented by a treating physician at sites experienced in managing patients with HF according to guidelines; (Paper II) to investigate how to define a responder regarding optimal cut-off level of BNP to predict death, need for hospitalisation, and worsening HF and to determine the optimal time to apply the chosen cut-off value; (Paper III) to evaluate how Health-Related Quality of Life (HR-QoL) is influenced by natriuretic peptide guiding and to study how HR-QoL is affected in responders compared to non-responders; (Paper IV) to evaluate the impact of patient age on clinical outcomes, and to evaluate the impact of duration of the HF disease on outcomes and the impact of age and HF duration on BNP concentration. LÄS MER

  3. 2. Mineralocorticoid receptor antagonists in heart failure : exploring the gap between guideline-directed medical therapy and real-world practice

    Författare :Anna Jonsson Holmdahl; Krister Lindmark; Helena Norberg; Ellinor Bergdahl; Fredrik Valham; Niklas Bergh; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Heart failure; Mineralocorticoid receptor antagonists; estimated glomerular filtration rate; hyperkalemia; impaired renal function; worsening renal function; guideline-directed medical therapy; kardiologi; Cardiology;

    Sammanfattning : Heart failure is the possible end-result of a variety of different diseases, where ischemic heart disease and hypertension are the most common causes in high income countries. In Sweden, heart failure has a prevalence of 2% in the adult population and rises to over 10% among people over 70 years of age. The 5-year all-cause mortality is about 50%. LÄS MER

  4. 3. Cardiac Resynchronization Therapy - Risk Stratification and Long-Term Outcome

    Författare :Christian Reitan; Kardiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cardiac Resynchronization Therapy; heart Failure; Device therapy; long-term outcome;

    Sammanfattning : Heart failure is a condition that will affect 2-3% of the population. Around one third of the patients have a decreased LVEF and a widened QRS complex as a sign of ventricular dyssynchrony. CRT has emerged as a treatment that reduces morbidity, mortality and improve functional status in this population. LÄS MER

  5. 4. Behind the Screen : -Internet-Based Cognitive Behavioural Therapy to Treat Depressive Symptoms in Persons with Heart Failure

    Författare :Johan Lundgren; Peter Johansson; Tiny Jaarsma; Anita Kärner Köhler; Gerhard Andersson; Cecilia Fagerström; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cognitive behavioural therapy; Depression; Heart failure; Internet-based cognitive behavioural therapy; Patients’ experiences; Self-care; Telehealth; Depression; Egenvård; Hjärtsvikt; Internetbaserad kognitiv beteendeterapi; Kognitiv beteendeterapi; Patienters upplevelse; Telehälsa;

    Sammanfattning : IntroductionThe prevalence of depressive symptoms in persons with heart failure is higher than in age- and gender-matched populations not suffering from heart failure. Heart failure in itself is associated with an unpredictable trajectory of symptoms, a poor prognosis, high mortality and morbidity, and low health-related quality of life (HrQoL). LÄS MER

  7. 5. Clinical aspects of restorative treatment in the primary dentition

    Författare :Mirja Varpio; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Child; Child; Preschool; Cohort Studies; Composite Resins; chemistry; DMF Index; Dental Caries; epidemiology; microbiology; pathology; therapy; Dental Cavity Preparation; classification; Dental Enamel; pathology; Dental Restoration; Permanent; statistics numerical data; Follow-Up Studies; Glass Ionomer Cements; chemistry; Humans; Molar; Prevalence; Prosthesis Failure; Recurrence; Sweden; epidemiology; Tooth; Deciduous;

    Sammanfattning : The failure rate of restorative treatment in primary teeth was studied in a cohort of children born in 1981 and related to caries diagnosis, prevalence and distribution on different tooth surfaces, and compared with a cohort of children born in 1971. Concurrently, the longevity of composite resin in modified Class 2 cavities in primary molars was followed up and the resistance of deciduous and permanent enamel to acid adjacent to composite resin and glass polyalkeonate cement (GPA) was tested in vitro. LÄS MER