Sökning: "sandra irenaeus"

Hittade 1 avhandling innehållade orden sandra irenaeus.

1. 1. Intratumoral CD40 stimulating therapy in patients with advanced cancer

   Författare :Sandra Irenaeus; Gustav Ullenhag; Angelica S. Loskog; Poulam Patel; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD40; CD40L; immunotherapy; early clinical studies; advanced cancer; intratumoral administration; Medicinsk vetenskap; Medical Science; Oncology; Onkologi;

   Sammanfattning : CD40-CD40L interaction activates DCs to become highly efficient APCs and skews the adaptive immune response towards a Th I phenotype driving cytotoxic T cells, M1 macrophages and natural killer cells. Furthermore, engagement of CD40L to CD40 positive cancer cells can have direct anti-proliferative effects, induce apoptosis and increase expression of MHC and other co-stimulatory molecules, thereby enhancing cancer cell recognition. LÄS MER