Sökning: "overksam"

Hittade 2 avhandlingar innehållade ordet overksam.

1. 1. Studies on the enantioselective disposition of amlodipine : A challenge in bioanalysis

   Författare :Martin Josefsson; Martin Ahnoff; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : To study the disposition of the enantiomers of the calcium channel blocker amlodipine in human plasma, an enantioselective high performance liquid chromatographic (HPLC) assay was developed. Several HPLC techniques such as chiral ion-pair forming, chiral derivatisation and direct separation on chiral columns were evaluated. LÄS MER

3. 2. Metabolism of quinoline 3-carboxamide compounds, a group of synthetic immunomodulators, in various species

   Författare :Helen Tuvesson; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; enzymologi; Proteiner; enzymology; Proteins; Gastroenterologi; Gastro-enterology; pharmacokinetics; enzyme kinetics; quinoline 3-carboxamides; Keywords: Metabolism; cytochrome P450;

   Sammanfattning : Cytochrome P450 (CYP) is involved in the metabolism of the majority of clinically used drugs. We have studied the CYP mediated metabolism of quinoline 3-carboxamides, a group of synthetic immunomodulators in liver microsomal preparations from various species. LÄS MER