Sökning: "kinetic isotope effect"
Visar resultat 1 - 5 av 18 avhandlingar innehållade orden kinetic isotope effect.
1. Isotopes as Mechanism Spies : Nucleophilic Bimolecular Substitution and Monoamine Oxidase B Catalysed Amine Oxidation Probed with Heavy Atom Kinetic Isotope Effects
Sammanfattning : This thesis concerns the study of reaction mechanisms by means of kinetic isotope effects (KIEs). Studies of the nucleophilic bimolecular substitution (SN2) reaction had the dual purpose of improving our fundamental understanding of molecular reactivity and assessing the ability of kinetic isotope effects to serve as mechanistic tools. LÄS MER
2. Multiple Kinetic Isotope Effect Study of an Elimination Reaction
Sammanfattning : .... LÄS MER
3. Concerted or Stepwise? : β-Elimination, Nucleophilic Substitution, Copper Catalysed Aziridination and Ruthenium Catalysed Transfer Hydrogenation Studied by Kinetic Isotope Effects and Linear Free-Energy Relationships
Sammanfattning : This thesis describes the use of kinetic isotope effects, linear free energy relationships and stereochamical studies to distinguish between different mechanistic alternatives and to obtain information about transition state structure.In the first part fluorine and deuterium kinetic isotope effects were determined for the base promoted HF elimination from 4-fluoro-4-(4’-nitrophenyl)butane-2-on. LÄS MER
4. Volume kinetic development and application
Sammanfattning : Background: Fluid therapy is a cornerstone in shock resuscitation in a such as treatment of anesthesia induce down regulation of the circulation and also restores many different types of dehydrated states. Current guidelines for fluid therapy are, however, based on experience, rules of thumb and effect-related end points, such as restoration of physiological parameters, which do not directly represent the volume effect of the fluid. LÄS MER
5. Proton, Electron, and O2 transfer in Cytochrome c Oxidase
Sammanfattning : In mitochondria and aerobic bacteria energy conservation involves electron transfer through the membrane-bound protein of the respiratory chain to oxygen. Cytochrome c oxidase (CcO) catalyzes the reduction of oxygen to water. Part of the energy released in this reaction is used to pump protons across the membrane. LÄS MER