Sökning: "hemoglobin adducts"

Visar resultat 11 - 15 av 22 avhandlingar innehållade orden hemoglobin adducts.

  1. 11. Biomonitoring of epichlorohydrin and some related compounds

    Författare :Helena Hindsø Landin; Bo Jönsson; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Biomarkers; DNA Adducts; Epichlorohydrin; Glycidol; Hemoglobin adducts.; Physical Biology; fysikalisk biologi;

    Sammanfattning : This thesis considers epichlorohydrin (ECH), an important industrial chemical, that has been shown to be a carcinogen in experimental animals. The aim of this work is to improve the scientific basis for risk estimation of ECH and to suggest a reliable biomonitoring method for exposure. LÄS MER

  3. 12. Protein adducts in plasma as biomarkers of exposure to and risk of organic acid anhydrides

    Författare :Seema Rosqvist; Neurokirurgi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; GC-MS; IgG; IgE; exposure-response; serum albumin; biological monitoring; Hexahydrophthalic anhydride; methylhexahydrophthalic anhydride; OEL; Occupational health; industrial medicine; Yrkesmedicin; arbetsmiljömedicin;

    Sammanfattning : Organic acid anhydrides (OAAs) are important industrial chemicals but also potent inducers of airways diseases. Many exposed workers develop specific IgE and IgG antibodies. Hexahydrophthalic anhydride (HHPA) and methylhexahydrophthalic anhydride (MHHPA) are two particularly sensitising OAAs. LÄS MER

  4. 13. In vivo dosimetry of some important industrial chemicals by measurement of their reaction products with hemoglobin

    Författare :Hermes Licea Pérez; Åke Bergman; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Physical Biology; fysikalisk biologi;

    Sammanfattning : Hemoglobin adduct measurements provide a useful tool for the development of models for risk assessment of chemicals. The measurements can be used to identify reactive metabolites and to determine the in vivo doses of these metabolites. LÄS MER

  5. 14. In vivo dosimetry of some alkylating agents as a basis for risk estimation

    Författare :Dan Segerbäck; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The present study concerns in vivo dosimetry of ultimate electrophilic reagents as a step in risk estimation of mutagenic and carcinogenic chemicals. The level of reaction products with nucleophilic groups in macromolecules could be used for dose determination. LÄS MER

  7. 15. In vivo dosimetry of aldehydes and studies on the origin of malonaldehyde

    Författare :Antti Kautiainen; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Aldehydes are electrophilic reagents that bind to nucleophilic sites in macromolecules andmany of them have been shown to possess cytotoxic and genotoxic properties.The aim of this study was to develop an analytical method for the measurement of reactionproducts (adducts) of aldehydes with hemoglobin (Hb) and to apply this method for in vivodosimetry of endogenously formed aldehydes, particularly malonaldehyde (MA). LÄS MER