Sökning: "hTERT"

Visar resultat 21 - 25 av 30 avhandlingar innehållade ordet hTERT.

  1. 21. Preclinical therapeutic vaccination strategies in malignancies with focus on B-cell chronic lymphocytic leukemia

    Författare :Parviz Kokhaei; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Immunotherapy; dendritic cells. chronic lymphocytic leukemia; tumor vaccine; T lymphocyte;

    Sammanfattning : A therapeutic strategy that may potentially delay progression or prevent relapse of B-cell chronic lymphocytic leukemia (B-CLL), is anti-leukemic vaccine therapy. This thesis focuses on comparing different strategies for loading antigen on dendritic cells (DC) with the aim of delineating the most effective antigen presentation platform for stimulating anti-leukemic T cells. LÄS MER

  3. 22. Novel mechanisms in depression: focus on telomere biology and epigenetic regulation

    Författare :Yabin Wei; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Telomere length;

    Sammanfattning : Depression is a complex disorder with an average lifetime prevalence from 11.1% to 14.6%. It causes serious disability and is a significant public health problem worldwide. LÄS MER

  4. 23. p16INK4A and p15INK4B in senescence, immortalization and cancer : gene transfer by adenovirus vectors

    Författare :Jonas Fuxe; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The astrocytic gliomas are the most common form of brain tumors in humans. The malignant progression from low grade (astrocytoma, grade II) to high-grade (glioblastoma multiforme, grade, IV) astrocytomas is well documented and is accompanied by an increasing number of genetic aberrations. LÄS MER

  5. 24. Pheochromocytoma and abdominal paraganglioma : clinical and genetic aspects

    Författare :Elisabet Edström Elder; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Pheochromocytomas; abdominal paragangliomas; RET; MEN 2A; tumour development; chromosome 1; comparative genomic hybridisation; in situ hybridization; loss of heterozygosity.;

    Sammanfattning : Pheochromocytomas and abdominal paragangliomas are rare catecholamine producing tumours arising from sympathoadrenal paraganglia located within and outside of the adrenal medulla, respectively. The great majority of tumours are benign and cured by surgery. LÄS MER

  7. 25. Roles of Myc and Mad in cell cycle and apoptosis

    Författare :Ami Albihn; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Myc; Mad; cell cycle; apoptosis; differentiation; tumorigenesis; chemotherapy;

    Sammanfattning : The Myc network proteins are key mediators in regulation of cell growth, differentiation and apoptosis. They are basic region hehx-loop-helix/leucine zipper (bHLH/Zip) transcription factors that require hetero-dimerization with Max for specific DNA binding Mad family members are expressed primarily in differentiated tissues where they recruit histone deacetylase complexes via the mSin3 interaction domain (SID) to repress transcription of target genes and prevent cell growth In contrast, members of the Myc family activate target gene transcription by recruitment of histone acetyltransferases to their transcriptional activation domain (TAD), inducing proliferation and S phase entry. LÄS MER