Sökning: "hTERT"

Visar resultat 11 - 15 av 30 avhandlingar innehållade ordet hTERT.

  1. 11. Angiostatic mechanisms of endogenous angiogenesis inhibitors

    Författare :Niina Veitonmäki; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Angiogenesis; tumor growth; angiostatin; K 1 - 5; adiponectin; hTERT; p16;

    Sammanfattning : Angiogenesis, the process of sprouting of new capillaries from the existing blood vessels, is essential for tumor growth and metastasis. Angiostatin was discovered as the first specific endogenous angiogenesis inhibitor nearly 10 years ago. The structure of angiostatin consists of the first three/four kringle (K1-3/K1-4) domains of plasminogen. LÄS MER

  3. 12. The p53 pathway : role of telomerase and identification of novel targets : acts of a master regulator of tumor suppression

    Författare :Rabaiyat Rahman-Roblick; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : A key role of the p53 protein in tumor suppression is reflected by its frequent mutations in human tumors. p53 is activated by various types stress conditions such as DNA damage, hypoxia and oncogene activation that results in p53-mediated cellular responses including DNA repair, cell cycle arrest, and apoptosis. LÄS MER

  4. 13. Immunological and molecular studies for the development of vaccine therapy for chronic lymphocytic leukemia

    Författare :Marzia Palma; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Chronic lymphocytic leukaemia (CLL) is a malignant lymphoproliferative disorder which typically affects elderly people. It is the commonest leukemia in the Western adults, accounting for 25-30% of all leukemias and for 10% of all hematological neoplasms. LÄS MER

  5. 14. Integration of Molecular Biology and Morphology in Effusions with Focus on in situ Detection of Telomerase and its Components

    Författare :Nooreldin Zendehrokh; Malmö Patologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pathological anatomy; Patologi allmän ; patologisk anatomi; Diagnostics; Diagnostik; cancer; TRAP in situ; onkologi; Cytologi; cancerology; oncology; Cytology; Medicin människa och djur ; Medicine human and vertebrates ; General pathology; Telomerase;

    Sammanfattning : Clinical cytology is a rapid method to detect malignancy in effusions of the serous cavities, but the morphological characteristics of the cells do not always allow diagnosis and a specific marker for malignant cells would improve the diagnostic performance. Telomerase adds telomere repeats to the chromosome ends. LÄS MER

  7. 15. Human 15-lipoxygenase-1 and telomerase gene expression in cancer and inflammation

    Författare :Cheng Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Human 15-lipoxygenase type 1 (15-LOX-1) is an enzyme that catalyzes the oxygenation of free or membrane-bond polyunsaturated fatty acids containing at least one bis-allylic methylene moiety. The enzyme has been proposed to be involved in various physiological and pathophysiological activities including inflammation, apoptosis, cell maturation and tumorigenesis. LÄS MER