Sökning: "genome-scale metabolic modeling"
Visar resultat 1 - 5 av 16 avhandlingar innehållade orden genome-scale metabolic modeling.
1. Utilization of single-cell RNA-Seq and genome-scale modeling for investigating cancer metabolism
Sammanfattning : Cancer remains a leading cause of death worldwide, and its dysregulated metabolism is a promising target for therapy. However, metabolism is complex to study – the metabolism of a cell involves the interplay of thousands of chemical reactions that are combined in different ways across tissues and cell types. LÄS MER
2. Modeling human gut microbiota: from steady states to dynamic systems
Sammanfattning : Human gut microbes are an essential part of human sub-microscopic systems and involved in many critical biological processes such as Type 2 diabetes (T2D) and osteoporosis. However, the underlying mechanisms are unclear. LÄS MER
3. Systems Biology of Protein Secretion in Human Cells: Multi-omics Analysis and Modeling of the Protein Secretion Process in Human Cells and its Application
Sammanfattning : Since the emergence of modern biotechnology, the production of recombinant pharmaceutical proteins has been an expanding field with high demand from industry. Pharmaceutical proteins have constituted the majority of top-selling drugs in the pharma industry during recent years. LÄS MER
4. Metabolic Modeling of the Gut Microbiome-Host Interactions and Meta’omics Integration
Sammanfattning : A large number of microbes with different strain types occupy the human gut. These gut inhabitant microbes have key roles in decomposition of indigestible dietary macronutrients before they are metabolised by the host. LÄS MER
5. A systems biology understanding of protein constraints in the metabolism of budding yeasts
Sammanfattning : Fermentation technologies, such as bread making and production of alcoholic beverages, have been crucial for development of humanity throughout history. Saccharomyces cerevisiae provides a natural platform for this, due to its capability to transform sugars into ethanol. LÄS MER