Sökning: "ganciclovir"

Visar resultat 6 - 10 av 18 avhandlingar innehållade ordet ganciclovir.

  1. 6. Human cytomegalovirus : development of resistance to antiviral drugs and mechanisms of NK-cell evasion

    Författare :Mehrdad Mousavi-Jazi; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Human cytomegalovirus (HCMV), a member of the herpesviridae, is ubiquitous and causes persistent infections mostly without any clinical symptoms. However, HCMV infection is a major cause of morbidity and mortality among immunocompromised patients, especially transplant recipients and patients with AIDS. LÄS MER

  3. 7. New potential targets in medulloblastoma therapy : studies on cellular mechanisms and mediators

    Författare :Ninib Baryawno; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Medulloblastoma is an embryonal tumour that mainly affects children. It is the most common malignant brain tumour in children and accounts for 15% of all childhood brain tumours. It most often presents in the cerebellum and is considered to be a disorder of normal development. LÄS MER

  4. 8. Combination chemotherapy for human immunodeficiency virus infection

    Författare :Sarah Palmer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The worldwide spread of human immunodeficiency virus (HIV) has spurred the search for effective drugs to combat this deadly virus. The limited effect of monotherapy treatment, in large measure due to the development of drug resistant viral strains, has led to increased emphasis on combination chemotherapy for the treatment of HIV, the focus of this study. LÄS MER

  5. 9. Structural Studies of Proteins involved in Nucleotide Metabolism : Studies of a ribonucleotide reductase from A. aeolicus and NUDT15

    Författare :Daniel Rehling; Pål Stenmark; Gisela Brändén; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; X-ray crystallography; ribonucleotide reductase; NUDT15; Biochemistry; biokemi;

    Sammanfattning : This thesis is separated into two parts. The first part concerns ribonucleotide reductase from Aquifex aeolicus. A. aeolicus is a hyperthermophilic bacterium that thrives at extremely high temperatures of 80-95 °C. LÄS MER

  7. 10. Human cytomegalovirus in congenital infections and embryonal malignancies of the nervous system

    Författare :Nina Wolmer Solberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cytomegalovirus (CMV) is a herpesvirus that may cause severe or even fatal disease in immunocompromised patients as well as severe developmental disturbances in foetuses infected in utero. In contrast, only mild symptoms are generally observed in immunocompetent individuals. Virus infections are very common in and the global prevalence is 70-90%. LÄS MER