Sökning: "ex-vivo model"

Visar resultat 1 - 5 av 161 avhandlingar innehållade orden ex-vivo model.

  1. 1. Ultrasonic Methods for Quantitative Carotid Plaque Characterization

    Författare :Erik Widman; Matilda Larsson; Mark L. Palmeri; KTH; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Atherosclerosis; Cardiovascular Disease; Carotid Artery; Elasticity; ex vivo; in vivo; Phantom; Plaque; Polyvinyl Alcohol; Pulse Wave Imaging; Shear Wave Elastography; Speckle Tracking; Stroke; Ultrasound; Medical Technology; Medicinsk teknologi; Atherosclerosis;

    Sammanfattning : Cardiovascular diseases are the leading causes of death worldwide and improved diagnostic methods are needed for early intervention and to select the most suitable treatment for patients. Currently, carotid artery plaque vulnerability is typically determined by visually assessing ultrasound B-mode images, which is influenced by user-subjectivity. LÄS MER

  3. 2. Development of a New Biomechanical ex vivo Perfusion System - Studies on effects of biomechanical and inflammatory stress on hemostatic genes in human vascular endothelium

    Författare :Niklas Bergh; Göteborgs universitet; []
    Nyckelord :ex vivo perfusion system; biomechanical; endothelium; shear stress; tensile stress; pulsatile; TNF-α; JNK; hemostatic genes;

    Sammanfattning : The vascular endothelium is a multifunctional interface constantly exposed to biomechanical forces such as shear and tensile stress. Biomechanical stress is involved in the pathophysiological process of the vessel wall and thus affects vascular remodeling, atherosclerosis and thrombogenesis. LÄS MER

  4. 3. Aspects on the use of slowly degradable mesh in inguinal hernia surgery

    Författare :Fernando Ruiz-Jasbon; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; slowly degradable mesh; inguinal hernia; chronic post-operative pain; hernia recurrence; ex-vivo model;

    Sammanfattning : Background: Synthetic non-degradable mesh used in inguinal hernia surgery can cause chronic inflammation, which in turn can lead to chronic post-operative pain (CPP). Theoretically, a degradable mesh could reduce the risk of chronic pain. LÄS MER

  5. 4. Deciphering cell motility and spatial sensing of intestinal cell types using an ex vivo intestinal model

    Författare :Anna Webb; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The intestine is a highly organized tissue with two distinct regions: the crypt and the villus. When stem cells divide at the crypt bottom, half of their progeny migrates upwards towards the villus, where they differentiate into various cell types, including the abundant absorptive enterocytes. LÄS MER

  7. 5. Dynamic changes in T cell compartments and new approaches in evaluating DSS induced and Gai2 deficient colitis

    Författare :Maria Fritsch Fredin; Göteborgs universitet; []
    Nyckelord :colitis; Gai2- - mice; dextran sodium sulfate; ex vivo cultures; micro-Computed Tomography; IEL; thymus; Inflammatory Bowel Disease;

    Sammanfattning : The overall aim of this thesis was to increase the understanding of the immunopathology of Inflammatory Bowel Disease (IBD). The first aim was to elucidate how the thymus and the gut epithelium were affected by colitis. The second aim was to investigate new ways of assessing and monitoring colitis. LÄS MER