Sökning: "copy number aberration"

Visar resultat 11 - 13 av 13 avhandlingar innehållade orden copy number aberration.

  1. 11. Genomic changes defining the progression of human colorectal and cervical tumors

    Författare :Kerstin Heselmeyer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :colorectal; cervical; anal neoplasias proliferation; DNA ploidy; p53 and p21WAF1 expression; HPV; CGH;

    Sammanfattning : Defining changes during the carcinogenesis and progression of tumors is a major way to obtain a better understanding of the mechanisms of cancer development. We therefore investigated the carcinogenesis process in the colon-rectum and in the uterine cervix by different cell chemical, immunohistochemical and cytogenetic methods. LÄS MER

  3. 12. Towards Precision Medicine: Exploiting Genetic Variation in Tumours by Inferring Multitype Gene Regulatory Networks

    Författare :Tobias Abenius; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; precision medicine; survival; cancer; gene regulatory networks; high-dimensional data; LASSO; Reproducible research; Generalized Pairwise Fused LASSO; Split Bregman;

    Sammanfattning : Precision medicine aims to customize treatment to a patient given measured genetic or other molecular data for diagnostics. In cancer, optimal medical treatment, depends on how far the disease has progressed, type and subtype of cancer and, the individual tumor’s circumstances. LÄS MER

  4. 13. Hereditary predisposition and prognostic prediction in cancer

    Författare :Karin Wallander; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer is a genetic disease. The cancer cells evolve clonally through changes of their genome, gaining malignant characteristics. In hereditary cancer syndromes, a genetic aberration which puts the cells one step closer to being malignant is inherited and present throughout whole body. LÄS MER