Sökning: "clinical R D"

Visar resultat 1 - 5 av 44 avhandlingar innehållade orden clinical R D.

1. 1. Standardization of Islet Isolation and Transplantation Variables

   Författare :Andrew S Friberg; Olle Korsgren; Daniel Brandhorst; Paul R. V. Johnson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Islet isolation; standardization; enzyme; gradient separation; digital imaging analysis; DIA; transplantation outcome; islet transplantation; prediction; Medical technology; Medicinsk teknik; Medical Cell Biology; Medicinsk cellbiologi; Computerized Image Processing; Datoriserad bildbehandling;

   Sammanfattning : Currently, the transplantation of islets of Langerhans is a viable means to maintain control of blood sugar levels and reduce the risk of hypoglycemia in defined populations with brittle type I diabetes mellitus or those requiring pancreatectomy. However, the process of islet isolation is highly variable and not all isolations result in islet numbers or quality suitable for transplantation. LÄS MER

3. 2. “Dr Jekyll and Mr Hyde?” : Abuse of potent benzodiazepines, exemplified by flunitrazepam, in mentally disordered male offenders

   Författare :Anna Maria Dåderman; Marianne Kristiansson; Lars Lidberg; Ann Wirsén Meurling; Sten Levander; Fred Nyberg; Karolinska Institutet Division of Forensic Psychiatry Department of Clinical Neuroscience; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Flunitrazepam FZ abuse; side effects of FZ; offenders referred to forensic psychiatric evaluation; juvenile delinquents; personality traits; psychopathic traits and lifestyle PCL-R ; Psychology; Psykologi; Flunitrazepam FZ abuse; side effects of FZ; offenders referred to forensic psychiatric evaluation; juvenile delinquents; personality traits; psychopathic traits and lifestyle PCL-R .;

   Sammanfattning : Flunitrazepam (FZ) is an example of a sedative-hypnotic benzodiazepine whose pharmacokinetic properties include a rapid onset of action and an intermediate duration of action. It has a high affinity to central benzodiazepine receptors and affects them profoundly. LÄS MER

4. 3. Novel immunotherapies for metastatic uveal melanoma - From bench to clinical biomarkers

   Författare :Vasu R. Sah; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Sammanfattning : Immunotherapy has revolutionized cancer treatment, with durable long-term effects in a proportion of patients. However, in around half of these patients, there are little to no effects. Patients with metastatic uveal melanoma (mUM), a rare form of melanoma originating from the eye has lack of effective treatments. LÄS MER

5. 4. In vitro and in vivo studies of tissue engineering in reconstructive plastic surgery

   Författare :Fredrik R.M. Huss; Gunnar Kratz; Elof Eriksson; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tissue engineering; plastic surgery; guided tissue regeneration; Plastic surgery; Plastikkirurgi; Plastikkirurgi;

   Sammanfattning : To correct, improve, and maintain tissues, and their functions, are common denominators in tissue engineering and reconstructive plastic surgery. This can be achieved by using autolo-gous tissues as in flaps or transplants. However, often autologous tissue is not useable. LÄS MER

7. 5. Investigating problematic severe asthma in children : a translational approach

   Författare :Jon R Konradsen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Children with problematic severe asthma (PA) have persistent symptoms and/or severe exacerbations despite treatment with high doses of currently available asthma medications. The term PA includes children who are difficult to treat due to unidentified exacerbating factors (e.g. LÄS MER