Sökning: "cell-based assay"

Visar resultat 6 - 10 av 40 avhandlingar innehållade orden cell-based assay.

  1. 6. Identification and evaluation of antiviral compounds targeting Rift Valley fever virus

    Författare :Koushikul Islam; Clas Ahlm; Magnus Evander; Anna K. Överby; Johan Neyts; Umeå universitet; []
    Nyckelord :Rift Valley fever virus; antiviral; assay development; screening; drug discovery;

    Sammanfattning : Rift Valley fever virus (RVFV), a negative-stranded RNA virus, is the etiological agent of the vector-borne zoonotic disease Rift Valley fever (RVF). RVFV causes significant morbidity and mortality in humans and livestock throughout Africa and the Arabian Peninsula. LÄS MER

  3. 7. Identification of novel inducers for LL-37 expression : assay development and mechanistic studies

    Författare :Frank Nylén; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The remaining reservoir of effective antibiotics is running out and more and more pathogens are gaining resistance, even to the last line of antibiotics. Therefore, novel treatment regimens against bacterial infections are urgently needed. LÄS MER

  4. 8. Advanced Methods for Evaluation of the Performance of Complex Drug Delivery System

    Författare :Caroline Alvebratt; Christel Anna Sofia Bergström; Maria Strömme; Caitriona O'Driscoll; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; amorphous solid dispersion; coadministration; digestion; dissolution; drug absorption; enabling formulation; in vitro assay; lipid-based formulation; mesoporous carrier; supersaturation; Farmaceutisk vetenskap; Pharmaceutical Science;

    Sammanfattning : Low oral bioavailability of drugs originating from poor aqueous solubility is a common issue in drug development. Various enabling formulations have been presented to circumvent this limitation, many making use of supersaturation. In these, the drug is delivered to the gastro-intestinal lumen in a high energy state e.g. LÄS MER

  5. 9. Tertiary Alcohol- or β-Hydroxy γ-Lactam-Based HIV-1 Protease Inhibitors : Microwave Applications in Batch and Continuous Flow Organic Synthesis

    Författare :Per Öhrngren; Mats Larhed; Knud J. Jensen; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; HIV; AIDS; protease inhibitor; aspartic protease; lactam; tertiary alcohol; continuous-flow; microwave; non-resonant; MAOS; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : Since the outbreak of the HIV/AIDS pandemic in the 1980s, the disease has cost the lives of over 30 million people, and a further 33 million are currently living with the HIV infection. With the appropriate treatment, HIV/AIDS can today be regarded as a chronic but manageable disease. LÄS MER

  7. 10. Chemical attenuation of bacterial virulence : small molecule inhibitors of type III secretion

    Författare :Anna Kauppi; Mikael Elofsson; Anders Karlén; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; antibiotic resistance; virulence; type III secretion; T3SS inhibitors; Yop; SMD; QSAR; screening; Yersinia pseudotuberculosis; Organic chemistry; Organisk kemi;

    Sammanfattning : Despite the large arsenal of antibiotics available on the market, treatment of bacterial infections becomes more challenging in view of the fact that microbes develop resistance against existing drugs. There is an obvious need for novel drugs acting on both old and new targets in bacteria. LÄS MER