Sökning: "cardioprotection"

Visar resultat 1 - 5 av 18 avhandlingar innehållade ordet cardioprotection.

  1. 1. Myocardial ischemia-reperfusion and cardioprotection. A study with microdialysis in a porcine model

    Författare :Carsten Metzsch; Anestesiologi och intensivvård; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; heart preservation; metoprolol; levosimendan; beta-blockers; pharmacological preconditioning; myocardial ischemia; cardioprotection; glycerol; microdialysis; cold cardioplegic storage;

    Sammanfattning : The studies in this thesis are based on questions raised in the clinical setting. Perioperative myocardial ischemia occurs more often than recognized. This may lead to myocardial infarction, increased morbidity, mortality, and health care costs. LÄS MER

  3. 2. Cardioprotective treatment strategies

    Författare :Jesper vanderPals; Kardiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ADC-1004; apyrase; Cardioprotection; ischemia reperfusion; hypothermia; t-PA;

    Sammanfattning : In myocardial ischemia-reperfusion (I/R) injury, complement activation, tissue plasminogen activator (t-PA) and extracellular adenosine triphosphate (ATP) release contribute to myocardial injury. ATP is degraded into adenosine by the enzyme apyrase, and adenosine possesses cardioprotective properties. LÄS MER

  4. 3. Porcine myocardial ischemia-reperfusion studies on cardioprotection, ventricular arrhythmia and electrophysiology

    Författare :Jacob Odenstedt; Göteborgs universitet; []
    Nyckelord :porcine; myocardial ischemia; ventricular arrhythmia; sudden cardiac death; electrophysiology; vectorcardiography; endocardial mapping; spinal cord stimulation;

    Sammanfattning : Background: Coronary artery disease is the primary cause of death in adults in the industrialised world and ventricular fibrillation associated with myocardial ischemia is the main cause of sudden cardiac death. Restoration of blood flow and preservation of myocardial integrity throughout ischemia and reperfusion is essential to improve clinical outcome. LÄS MER

  5. 4. The importance of nitric oxide bioavailability and endothelial mechanisms for cardioprotection by pharmacological intervention during myocardial ischaemia and reperfusion

    Författare :Andrey Gourine; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ATP sensitive K channels; endothelin-1; clevidipine; ETA receptor antagonist; glibenclamide; 5-hydroxydecanoic acid; infarct size; ischaemia; myeloperoxidase; nitric oxide; nitric oxide synthase; pig; preconditioning; rat; reperfusion.;

    Sammanfattning : Myocardial ischaemia initiates complex severe cellular changes and, after a critical time period, myocardial cell death. Despite that restitution of coronary blood flow is an absolute pre-requisite for tissue survival, myocardial reperfusion per se will also increase irreversible damage in the jeopardised myocardium. LÄS MER

  7. 5. Sex Differences in Cardiac and Cerebral Damage after Hypovolemic Cardiac Arrest

    Författare :Egidijus Semenas; Sten Rubertsson; Lars Wiklund; Ala Nozari; Sven Erik Gisvold; Uppsala universitet; []
    Nyckelord :Cardiopulmonary resuscitation; sex; haemorrhage; neuronal damage; estradiol; hypertonic saline; nitric oxide; methylene blue; MEDICINE; MEDICIN; Anaesthesiology and Intensive Care; Anestesiologi och intensivvård;

    Sammanfattning : Resuscitation from haemorrhagic shock and the subsequent circulatory arrest remains a major clinical challenge in the care of trauma patients. Numerous experimental studies in sexually mature animals have shown a gender dimorphism in response to trauma and haemorrhagic shock. LÄS MER