Sökning: "bone marrow macrophages"

Visar resultat 1 - 5 av 57 avhandlingar innehållade orden bone marrow macrophages.

  1. 1. Peri-implantitis : treatment and effects of enamel matrix derivative

    Författare :Catrine Isehed; Pernilla Lundberg; Anders Holmlund; Leif Jansson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; implant; peri-implantitis; bone regeneration; enamel matrix derivative; surgical treatment; proteome; bone marrow macrophages; osteoclast formation; bone resorption; odontologi; Odontology;

    Sammanfattning : Biological complications affecting osseointegrated dental implants are a growing treatment problem in clinical practice. Since the number of implant carriers has increased in recent decades, this is an urgent topic in dentistry. LÄS MER

  3. 2. Identifying and targeting vulnerabilities in cancers that metastasize to the bone and bone marrow

    Författare :Adele Mirna Alchahin; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Evolving technologies enable scientist to ask and seek answers to advanced questions, above and beyond. During the past decade single-cell RNA sequencing (scRNA-seq) has revolutionized our understanding of biology, in particular within cancer research. LÄS MER

  4. 3. Vitamin A and Bone: Studies in vivo and in vitro

    Författare :Vikte Lionikaite; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; vitamin A; retinol; osteoclasts; osteoblasts; cortical bone; osteoporosis;

    Sammanfattning : Background: Excess vitamin A is associated with decreased cortical bone and increased risk of fractures in humans. The aim of the present thesis was to assess the importance of vitamin A on the skeleton and bone cells in in vivo animal studies and mechanistic in vitro experiments. LÄS MER

  5. 4. Functional aspects of prothrombin in bone

    Författare :Erik Karlström; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Prothrombin (PT) is the inactive zymogen to the serine protease alpha-thrombin which in the coagulation cascade is responsible for clot formation through converting fibrinogen to fibrin. PT has been shown to be present in calcified bone matrix, and alpha-thrombin has been implicated in various bone resorbing disorders of inflammatory origin, such as rheumatoid arthritis and periodontitis. LÄS MER

  7. 5. Determining the role of guanylate-binding proteins for host defense against Francisella tularensis

    Författare :Nasibeh Mohammadi; Anders Sjöstedt; Wolfgang P. Schröder; Anetta S. Härtlova; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Francisella tularensis; Guanylate-binding proteins; bone marrow-derived macrophages; IFN-γ activation; cytokine patterns; inflammasome pathways; co-infection; mouse co-culture model; Biochemistry; biokemi; immunologi; Immunology; mikrobiologi; Microbiology; molekylärbiologi; Molecular Biology; Infectious Diseases; infektionssjukdomar;

    Sammanfattning : Francisella tularensis is a highly virulent, intracellular bacterium and the causative agent of the human disease tularemia. This is a zoonotic, often vector-borne disease. Due to its intracellular nature, F. LÄS MER