Sökning: "binding mechanisms"

Visar resultat 1 - 5 av 1105 avhandlingar innehållade orden binding mechanisms.

1. 1. Evolution and Binding Mechanisms of Intrinsically Disordered Proteins

   Författare :Elin Karlsson; Per Jemth; Kaare Teilum; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Intrinsically disordered proteins; Protein evolution; Binding kinetics; Binding mechanisms; Biophysical characterisation; Medicinsk biokemi; Medical Biochemistry;

   Sammanfattning : Intrinsically disordered proteins (IDPs) make up a considerable fraction of the proteome in eukaryotic organisms. These proteins often act as hubs in interaction networks, harbouring multiple interaction with other proteins, and thus evolution has to walk a tightrope to accommodate new interactions while maintaining the previously established interactions. LÄS MER

3. 2. Binding Three Kinds of Vision

   Författare :Leo Poom; Myron Braunstein; Uppsala universitet; []
   Nyckelord :SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; Psychology; Attribute-invariance; binding; contours; edge linking; gestalt-laws; illusory contour; lateral interactions; neuronal mechanisms; tilt effect; vision; Psykologi; Psychology; Psykologi; Psychology; psykologi;

   Sammanfattning : Pictorial cues, together with motion and stereoscopic depth fields, can be used for perception and constitute ‘three kinds’ of vision. Edges in images are important features and can be created in either of these attributes. LÄS MER

4. 3. Probing Ligand Binding Mechanisms in Insulin-Regulated Aminopeptidases : Computational analysis and free energy calculations of binding modes

   Författare :Sudarsana Reddy Vanga; Hugo Gutiérrez-de-Terán; Johan Åqvist; Efstratios Stratikos; Uppsala universitet; []
   Nyckelord :Docking; Molecular Dynamics; Binding free energy; Linear Interaction Energy; Free Energy Perturbation; Insulin-Regulated Aminopeptidase; Angiotensin IV; Oxytocin; Vasopressin; HA08; Aryl sulfonamides; HFI compounds.;

   Sammanfattning : In recent years insulin-regulated aminopeptidase (IRAP) has emerged as a new therapeutic target for the treatment of Alzheimer’s disease and other memory-related disorders. So far, many potent and specific IRAP inhibitors had been disclosed, including peptides, peptidomimetics, and low-molecular-weight sulfonamides. LÄS MER

5. 4. Protein Folding, Binding and Evolution : PDZ domains and paralemmins as model systems

   Författare :Greta Hultqvist; Per Jemth; Ruth Nussinov; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Protein folding; evolution; binding; allostery; Paralemmin; PDZ domain;

   Sammanfattning : Proteins present at the synapse need to be multitasking in order to perform all vital functions in this limited space. In this thesis I have analyzed the function and evolution of such proteins, focusing on the PDZ domain and the paralemmin family. The PDZ domains bind to a wide variety of interaction partners. LÄS MER

7. 5. Mechanisms involved in adenovirus binding to and infection of host cells

   Författare :Cecilia Nyberg; Niklas Arnberg; Pierre Boulanger; Umeå universitet; []
   Nyckelord :Adenovirus; binding; infection; lactoferrin; coagulation factor IX and X; fiber; MEDICINE; MEDICIN;

   Sammanfattning : The adenovirus (Ad) family consists of 52 different human types, which are divided into seven species (A-G). Human Ads cause disease in the respiratory tract, lymphoid tissue, intestine, urinary tract, and/or in the eye. LÄS MER