Sökning: "airway smooth muscle"

Visar resultat 6 - 10 av 39 avhandlingar innehållade orden airway smooth muscle.

  1. 6. New Mediators and Novel Mechanisms in Allergic Airway Inflammation

    Författare :Malin Bryborn; Klinisk och experimentell allergiforskning; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; allergic airway inflammation; airway hyperreactivity; inflammatory mediators; S100A7; IL-4; proteomics; genetic variation; Charcot-Leyden crystal protein;

    Sammanfattning : Hyperresponsiveness and inflammation are major pathophysiological features of both allergic rhinitis and asthma. The mechanisms behind these are not fully understood. LÄS MER

  3. 7. Prostaglandin E2 as mediator and modulator of airway smooth muscle responses

    Författare :Jesper Säfholm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Prostaglandin E2 (PGE2) is a lipid mediator produced by virtually every cell of the human body. Because common non-steroidal anti-inflammatory drugs (NSAIDs) inhibit its biosynthesis, PGE2 is usually considered to be a ‘pro-inflammatory’ mediator. The role of PGE2 in the lung and airways has however always been unclear. LÄS MER

  4. 8. Regulation of experimentally induced airway obstruction

    Författare :Eva G. Lindström; Jan Lötvall; Linköpings universitet; []
    Nyckelord :airway obstruction; antigen; capsaicin; epithelium; inflammatory mediators; sensory neurons; tube preparation; tachykinins; formoterol; histamine; presynaptic inhibition; in vitro; guinea pig; MEDICINE; MEDICIN;

    Sammanfattning : Asthma is one of the commonest diseases in industrialized countries. The cause and mechanisms of !he disorder are still not fully unden;tood, al!hough it is known that inflammation in !he airways plays an important role. Inflammatory mediators, e.g. LÄS MER

  5. 9. Functional characterisation of receptors for cysteinyl leukotrienes in smooth muscle

    Författare :Eva Wikström Jonsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :cysteinyl leukotrienes; leukotriene receptor; histamine; antigen; smooth muscle; lipoxin; thromboxane; Schultz-Dale reaction;

    Sammanfattning : The cysteinyl leukotrienes (leukotriene C4, D4 and E4) have potent biological actions which significantly contribute to the airway obstruction in asthma. Several of these effects are blocked by drugs known as CysLT1-receptor antagonists, which have been introduced as new treatment for asthma. LÄS MER

  7. 10. Airway smooth muscle as a target in asthma : new insights into bronchorelaxation and hyperreactivity

    Författare :Martijn Manson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Patients with asthma suffer from reversible airway obstruction accompanied by airway hyperresponsiveness (AHR). Airway smooth muscle (ASM) is central to bronchoconstriction and AHR and is therefore the target of existing and potential new therapies for asthma. LÄS MER