Sökning: "ZAP-70"

Visar resultat 1 - 5 av 9 avhandlingar innehållade ordet ZAP-70.

  1. 1. Interfacing HPLC with MALDI- and ESI-MS for Automated High Sensitivity Analysis of Proteins and Peptides

    Författare :Tasso Miliotis; Lund Institutionen för kliniska vetenskaper; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; automated; phosphorylation; ZAP-70; peptides; proteins; comprehensive; multidimensional; two-dimensional; piezoelectric; microdispenser; flow-through; ESI-MS MS; Capillary HPLC; MALDI-TOF MS; Analytical chemistry; Analytisk kemi;

    Sammanfattning : The research described in this thesis has an interdisciplinary approach dealing with chemical, biological, and technical issues. One objective was to interface miniaturized liquid chromatography (LC) to mass spectrometry, i.e. MALDI-TOF MS and ESI-MS, in an unattended mode for high sensitivity determination of proteins and peptides. LÄS MER

  3. 2. T cells in patients with B-cell chronic lymphocytic leukemia (B-CLL) and multiple myeloma (MM) : an immunological study

    Författare :Shahryar Kiaii; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :T cell; B-cell Chronic Lymphocytic Leukemia ; Multiple Myeloma ; signaling; gene expression;

    Sammanfattning : There are several lines of evidence that T cells in patients with Multiple Myeloma (MM) and B-cell Chronic Lymphocytic Leukemia (B-CLL) are phenotypically aberrant. The overall aim of this thesis was to study T cells with a focus on TCR-signaling pathways in these two B-cell malignancies. The role of T-cells in B-CLL etiology was also examined. LÄS MER

  4. 3. Telomere length as prognostic parameter in chronic lymphocytic leukemia

    Författare :Pawel Grabowski; Göran Roos; Ylva Paulsson Karlsson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; telomere length; chronic lymphocytic leukemia; prognosis; longitudinal sampling; genomic aberrations; IGHV; CD38; ZAP70; prognostic factors; Pathology; Patologi; patologi; Pathology;

    Sammanfattning : B-cell chronic lymphocytic leukemia (B-CLL) is the most common leukemia among the adult population in western countries and accounts for 30-40% of all leukemias. With survival time ranging from months to decades, the clinical course of individual CLL patients is highly variable. LÄS MER

  5. 4. Neruons; regulators of CNS inflammation

    Författare :Yawei Liu; Neuroinflammation; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; Immunologi; serology; Immunology; T cells; inflammation; neuron; CNS; EAE MS; serologi;

    Sammanfattning : Neurons have been neglected as cells with major immune regulatory function. Here, we present novel data demonstrating that neurons are highly immune competent and play crucial role in regulation of T cell response and CNS inflammation. LÄS MER

  7. 5. Amino acid sequence and side chain specific synthetic receptors targeting protein phosphorylation

    Författare :Anil Incel; Frank Kjeldsen; Malmö universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; imprinted polymers; synthetic receptors; PTM; phosphorylation; enrichment; diagnosis;

    Sammanfattning : Antibodies have become a critical component of many diagnostic assays and are used for therapeutic purposes. Nevertheless they often fail to meet the strict performance demands raised in industry and in the clinic (e.g. stability, reproducibility, selectivity, affinity). LÄS MER