Sökning: "Vladislav Kuzin"

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1. 1. Investigating novel roles of topoisomerase regulatory interactions in transcription

   Författare :Vladislav Kuzin; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Drugs targeting DNA Topoisomerases (TOPs, TOP1 and TOP2) are mainstays of anti-cancer therapy. While they have proven effective, the toxicity of current TOP drugs caused by DNA damage-induced apoptosis of non-cancer cells, limits their use in the clinic. LÄS MER