Sökning: "Tumor Antigen-presenting Cells"

Visar resultat 1 - 5 av 27 avhandlingar innehållade orden Tumor Antigen-presenting Cells.

1. 1. Restoring antitumor immunity with dendritic cell reprogramming strategies. Reprogramming cancer cells to antigen-presenting cells

   Författare :Alexandra Gabriela Barros Ferreira; Avdelningen för molekylärmedicin och genterapi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell Reprogramming; Cancer cells; Tumor Antigen-presenting Cells; immunotherapy;

   Sammanfattning : For the past two decades, immunotherapy revolutionized cancer treatment. However, responses vary significantly among eligible patients and some cancer types are not yet open to immunotherapy. Several mechanisms contribute to immunotherapy resistance, including loss of antigen presentation machinery and immunosuppression. LÄS MER

3. 2. CD40L Gene Therapy for Solid Tumors

   Författare :Lina Liljenfeldt; Thomas Tötterman; Angelica Loskog; Sara Mangsbo; Evren Alici; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD40L; adenovirus; tumor immunology; tumor microenvironment; immunotherapy; local immunotherapy; antigen presentation; Immunologi; Immunology;

   Sammanfattning : Adenoviral CD40L gene therapy (AdCD40L) is a strong inducer of anti-tumor immune responses via its activation of dendritic cells (DCs). Activated DCs can in turn activate T cells, which are key players in an efficient anti-tumor response.This thesis includes three papers that focus on different aspects of AdCD40L gene therapy. LÄS MER

4. 3. Requirements for the Induction of Adaptive Immune Responses to Rotavirus

   Författare :Joy Nakawesi; Virusrekognition; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rotavirus; classical dendritic cells; Lymphoid organ hypertrophy; B cells; IgA; Retinoic acid; CD8 T cells; TLR3 and Poly I:C ;

   Sammanfattning : Rotavirus (RV) infections remain the leading cause of world-wide diarrhea-associated morbidity and mortality among children 200,000 deaths annually mostly in the low-income countries of Africa and Asia. Efficient clearance of the primary RV infection and protection from future re-infections is mediated by adaptive immune responses. LÄS MER

5. 4. Tumor recognition by cytotoxic T cells : definition of new tumor antigens and the effect of interleukin-10 on antigen presentation

   Författare :Flavio Salazar-Onfray; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The tumor antigens against which T cell responses have been demonstrated most frequently are not tumor specific but are also expressed on normal tissues. This observation has been interpreted as evidence for breaking of immunological tolerance to normal cellular proteins. LÄS MER

7. 5. The HER2/neu oncoprotein and dendritic cells in immunity against tumors

   Författare :Yang Rongcun; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :HER2 neu; dendritic cells; ovarian carcinoma; apoptosis;

   Sammanfattning : It is now well established that small peptide epitopes bound to the major histocompatibility complex (MHC), derived from processed proteins synthesized by the tumor cells, can be recognized as antigens by cytotoxic T lymphocytes (CTLs). A number of tumor antigens recognized by CTLs on human melanomas have been defined, but less is known about antigens from other tumor types. LÄS MER