Sökning: "TLR"

Visar resultat 6 - 10 av 107 avhandlingar innehållade ordet TLR.

  1. 6. Function of natural killer cells in Helicobacter pylori infection and gastric cancer

    Författare :Åsa Lindgren; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Natural killer cells; Helicobacter pylori; gastric cancer; IFN-γ; TLR;

    Sammanfattning : Helicobacter pylori infection is one of the most wide-spread infections in the world and causes a chronic inflammation in the gastrointestinal mucosa characterised by increased production of IFN-γ and is associated with an increased risk of developing gastric cancer. The mechanisms behind the development of gastric cancer in H. LÄS MER

  3. 7. Intracellular regulation of TLR signaling Basic mechanisms and importance in intestinal inflammation

    Författare :Martin Berglund; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TLR IL-1R signalling; Gαi2- - mice; IRAK; peritoneal macrophages; cross-tolerance; dextran sulfate sodium; IBD;

    Sammanfattning : Toll-like receptors (TLRs) recognize conserved structures on/in microorganisms. The intracellular signalling pathways of TLRs are shared with IL-1R and IL-18R and their activation leads to transcription of proinflammatory cytokines and type-I interferons. LÄS MER

  4. 8. Effects of Complement Opsonization of HIV on Dendritic Cells : and Implications for the Immune Response

    Författare :Rada Ellegård; Marie Larsson; Jorma Hinkula; Johan D Söderholm; William Paxton; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; HIV; dendritic cells; complement; innate immune response; TLR signaling; T cell activation; NK cells; inflammation; antiviral response; immune evasion;

    Sammanfattning : Dendritic cells are key players during HIV pathogenesis, and shape both the immediate immune response at the site of infection as well as directing the adaptive immune response against the virus. HIV has developed a plethora of immune evasion mechanisms that hijack dendritic cell functions, suppressing their ability to mount an accurate immune response and exploiting them for efficient viral transfer to target T cells. LÄS MER

  5. 9. Adult neural stem cells in neuroinflammation

    Författare :Ruxandra Covacu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Neural stem cells; inflammation; EAE; NO; neurogenesis; HMGB1; TLR; TNFalpha;

    Sammanfattning : Adult neural stem cells (NSC) can be isolated from the subventricular zone (SVZ) of the lateral ventricles, the subgranular zone (SGZ) of the hippocampus and the central canal of the spinal cord. These cells are thought to have regenerative potential and pose important therapeutic possibilities in neuroinflammatory conditions such as Multiple Sclerosis (MS). LÄS MER

  7. 10. Immune responses in defined subgroups of patients with pulmonary sarcoidosis

    Författare :Farah Idali; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Sarcoidosis; Löfgren s syndrome; cytokine; regulatory T cell; TIM molecule; TLR;

    Sammanfattning : This thesis focuses on inflammatory responses in the airways of sarcoidosis patients. Sarcoidosis is a T helper 1-mediated inflammatory disease with unknown aetiology. HLA-DRB1*0301pos sarcoidosis patients often present with an acute form of disease, i.e. LÄS MER