Sökning: "T cell expansions"

Visar resultat 1 - 5 av 22 avhandlingar innehållade orden T cell expansions.

1. 1. T lymphocytes in Wegener’s granulomatosis

   Författare :Ricardo Antonio Giscombe Stephen; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Wegener s granulomatosis; T lymphocytes; TCR; T cell expansions; HLA-DRB1*0401; CTLA-4; IL-10;

   Sammanfattning : Wegener's granulomatosis (WG) is a systemic necrotizing vasculitis that affects small and medium size blood vessels. The respiratory tract and lungs are usually compromised with necrotizing granulomatous formations. The aetiology is unknown and untreated the prognosis of generalised WG is very poor. LÄS MER

3. 2. On CD4+ T Lymphocytes in Solid Tumours

   Författare :Per Marits; Ola Winqvist; Magnus Thörn; Alex Karlsson-Parra; Uppsala universitet; []
   Nyckelord :Molecular medicine; Tumour immunology; T lymphocytes; sentinel node detection; colon cancer; urinary bladder cancer; adoptive immunotherapy; Molekylärmedicin;

   Sammanfattning : This thesis deals with recognition and elimination of tumours by T lymphocytes and their use in adoptive immunotherapy.The first tumour-draining lymph node; the sentinel node, is identified by peritumoural injection of a tracer. This is the hypothesised location for the activation of tumour-reactive lymphocytes. LÄS MER

4. 3. T cell antigen receptor usage, phenotype and cytokine production in human diseases

   Författare :Jan Wahlström; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :T cell; T cell receptor; T cell expansion; phenotype; cytokine; extrinsic allergic alveolitis; allergic asthma; multiple myeloma; Wegener s granulomatosis; sarcoidosis;

   Sammanfattning : T lymphocytes are of critical importance for initiating and controlling immune responses, as the T cell receptor (TCR) for antigen allows a highly specific antigen recognition. Determination of TCR usage and characterization of T cell subsets in different diseases helps us understand the underlying immunopathogenic mechanisms, and may also lead to the development of new therapeutic approaches. LÄS MER

5. 4. T cell subsets and disease mechanisms in inflammatory myopathies

   Författare :Jayesh Pandya; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The idiopathic inflammatory myopathies (IIMs) are a heterogeneous group of chronic muscle disorders, typically displaying infiltrating T cells in skeletal muscle tissue and classified into polymyositis, dermatomyositis and sporadic inclusion body myositis. Several studies involving both humans and animal models point towards a role for T cells in the pathogenesis of IIMs, however, the precise phenotype, functionality and specificity of pathogenic T cells remain elusive. LÄS MER

7. 5. Studies of Regulatory T cells with Implications for Clinical Applications

   Författare :Marcus Bergström; Olle Korsgren; Wayne Hawthorn; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Regulatory T cell; Treg; Transplantation; Immunology; Tolerance; Islet transplantation; Immunosuppression; Immunologi; Immunology;

   Sammanfattning : Regulatory T cells (Tregs) are vital for regulating immune homeostasis and for preventing immunopathology. The immunosuppressive functions of Tregs have raised hope for their potential use in clinical applications. LÄS MER