Sökning: "Schizosaccharomyces pombe"

Visar resultat 6 - 10 av 28 avhandlingar innehållade orden Schizosaccharomyces pombe.

  1. 6. The CHD chromatin remodeling factors in schizosaccharomyces pombe

    Författare :Julian Walfridsson; Karl Ekwall; Pernilla Bjerling; Stefan Björklund; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Regulation of chromatin structure is essential in a wide variety of processes including transcriptional regulation, recombination, replication, chromosome segregation, development and differentiation. The enzymes that are central in regulating chromatin structure can be classified into two major groups. LÄS MER

  3. 7. The transcription machinery in schizosaccharomyces pombe and its regulation

    Författare :Henrik Spåhr; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Gene expression; transcription regulation; in vitro; RNA polymerase II; holoenzyme; mediator; TBP; TFIIB; TFIIF; TFIIH; Srb8-11; Pmc;

    Sammanfattning : The Mediator complex acts as a bridge, conveying regulatory information from enhancers and other control elements to the general transcription machinery. The Mediator was originally identified in Saccharomyces cerevisiae and is required for the basal and regulated expression of nearly all RNA polymerase II dependent genes. LÄS MER

  4. 8. Histone deacetylases and their co-regulators in schizosaccharomyces pombe

    Författare :Rebecka A. Silverstein; Karl Ekwall; Anthony Wright; Fred Van Leeuwen; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The DNA in every eukaryotic cell is wrapped around eight core histones to form the nucleosome. Therefore all events that involve DNA must also involve chromatin and nucleosomes. By regulating chromatin structure the cell can regulate the reactivity of the DNA. LÄS MER

  5. 9. DNA checkpoint override and redox signaling in Schizosaccharomyces pombe

    Författare :Johanna J Sjölander; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Caffeine; Cell cycle; Checkpoint; Cdc25; Wee1; TORC1; FHIT; Proliferation; Aph1; Redox; Hypoxia; H2O2; Cysteine; Thiol; Allosteric; MAPK; Sty1; MAPKK; Wis1;

    Sammanfattning : This thesis covers intracellular stress signaling through genotoxic stress, overriding of checkpoint control, as well as cellular redox status in hypoxic and oxidative stress Papers I and II: Caffeine has been shown to override cell cycle checkpoints in humans as well as in the fission yeast Schizosaccharomyces pombe. Understanding of the mechanism may aid in the development of compounds with similar overriding mechanisms for sensitization in cancer therapy. LÄS MER

  7. 10. Genome-wide study of HDACs and transcription in Schizosaccharomyces pombe

    Författare :Marianna Wirén; Karl Ekwall; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : The eukaryotic genome has to be organized to fit into the cell and this is achieved by packing of DNA into chromatin. The basic repeating structural unit of chromatin is the nucleosome, which consists of DNA wrapped around histone proteins. LÄS MER