Sökning: "MAPK"

Visar resultat 1 - 5 av 72 avhandlingar innehållade ordet MAPK.

1. 1. Ras-MAPK signaling in differentiating SH-SY5Y human neuroblastoma cells

   Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

   Författare :Anna-Karin Olsson; Uppsala universitet.; [2000]
   Nyckelord :MEDICIN; MEDICINE; Genetics; Neuroblastoma; SH-SY5Y; differentiation; neurite; Ras; MAPK; PKC; Genetik; patologi; Pathology;

   Sammanfattning : Neuroblastoma is a malignant childhood cancer, originating from sympathetic neuroblasts of the peripheral nervous system. Neuroblastoma is a heterogenous group of tumours, while some are highly malignant others can spontaneosly mature into a more benign form or regress. LÄS MER

3. 2. Downstream functions of the Sty1 MAPK pathway in S. pombe

   Detta är en avhandling från University of Gothenburg

   Författare :Eva Asp; Göteborgs universitet.; University of Gothenburg.; [2007]
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; S.pombe; MAPK; Sty1; Mkp1; oxidative stress; translation; mRNA stability;

   Sammanfattning : MAP kinase pathways are involved in the response to environmental changes in eukaryotic cells regulating transcriptional and translational events. In S. LÄS MER

4. 3. p38 MAPK Signalling in Endothelial Apoptosis

   Detta är en avhandling från Departement of Laboratory Medicine

   Författare :Simone Grethe; Lunds universitet.; Lund University.; [2005]
   Nyckelord :MEDICIN; MEDICINE; Natural science; Naturvetenskap; PP2A; Bad; Bcl-xL; doxorubicin; TNF; p38 MAPK; Apoptosis; endothelial cells;

   Sammanfattning : Endothelial apoptosis plays an important role in atherosclerosis, and a direct proapoptotic effect of chemotherapeutics on the tumour vasculature, emphasizes the great potency of antiangiogenic therapy in the treatment of cancer. We investigated signalling pathways in endothelial apoptosis induced by the inflammatory cytokine tumour necrosis factor alpha (TNF), the main target of which is the endothelium, and by the anticancer drug doxorubicin. LÄS MER

5. 4. Regeneration of Peripheral Nerves. The role of protein kinases, with emphasis on neurotrophic factor stimulation

   Detta är en avhandling från Peter Wiklund, Zenithgatan 3 SE-212 14 Malmö, Sweden

   Författare :Peter Wiklund; Lunds universitet.; Lund University.; [1999]
   Nyckelord :MEDICIN; MEDICINE; NT-3; NT-4; NGF; MAPK; PKG; PKA; PKC; nodose ganglion; DRG; conditioning effect; neurotrophic factors; protein kinases; peripheral; nerve regeneration; BDNF; GDNF; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

   Sammanfattning : The purpose of this study was to investigate the role of protein kinases in peripheral nerve regeneration, with the use of dorsal root ganglia (DRG) and nodose ganglia explants from adult mice. The effects of neurotrophic factor stimulation and protein kinase inhibition were studied for long (days) and short term (minutes) effects. LÄS MER

7. 5. MEKK-1 and NF-κB Signaling in Pancreatic Islet Cell Death

   Detta är en avhandling från Uppsala : Acta Universitatis Upsaliensis

   Författare :Dariush Mokhtari; Uppsala universitet.; [2008]
   Nyckelord :Cell biology; MEKK-1; JNK; human islets; β-cells; siRNA; apoptosis; cell death; MAPK; nitric oxide; cytokines; streptozotocin; c-Rel; NF-κB; Cellbiologi;

   Sammanfattning : Type 1 diabetes is an autoimmune disease resulting in the selective destruction of the insulin producing β-cells in the pancreas. Pro-inflammatory cytokines and the free radical nitric oxide (NO) have been implicated in mediating the destruction of β-cells, possibly through activation of the mitogen activated protein kinases (MAPKs) JNK, ERK and p38. LÄS MER