Sökning: "Samhd1"

Hittade 4 avhandlingar innehållade ordet Samhd1.

  1. 1. Pathology of dNTP dysregulation

    Författare :Phong Tran; Andrei Chabes; Erik Johansson; Ola Hammarsten; Umeå universitet; []
    Nyckelord :dNTP metabolism; DNA replication; mutation rate; cancer; heart development; RNR; SAMHD1; Rrm1; Samhd1; medicinsk biokemi; Medical Biochemistry;

    Sammanfattning : Deoxyribonucleoside triphosphates (dNTPs) are precursors for DNA replication and repair. Mammalian cells have two distinct biosynthesis pathways to supply dNTPs: de novo and salvage pathways. LÄS MER

  3. 2. Translational studies on antimetabolic therapies in paediatric oncology

    Författare :Nikolaos Tsesmetzis; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cure rates for paediatric and adult cancer patients have improved within the last decades. This can partly be explained by implementation of new technologies and methodologies such as the identification of new mutations after sequencing that can be directly targeted for treatment or the introduction of immunotherapy. LÄS MER

  4. 3. Identification and characterization of novel genetic and epigenetic factors required for normal and malignant hematopoiesis

    Författare :Yaser Heshmati; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Acute myeloid leukemia (AML) is a type of blood cancer, characterized by clonal expansion and loss of differentiation ability of myeloid progenitor cells leading to abnormal accumulation of immature myeloid cells (myeloblasts) in the bone marrow and peripheral blood. This thesis (study I to IV) focused on the identification and characterization of genes which are required for AML growth. LÄS MER

  5. 4. HIV-1 Exploitation of Dendritic Cell Functionality and Initial Responses in Mucosal Tissues : Elucidation of Influence of HIV-1 Complement Opsonization, and HIV-1-HSV-2 Co-infection

    Författare :Cecilia Svanberg; Marie Larsson; Sofia N. Nyström; Jorma Hinkula; Marianne Jansson; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Human immunodeficiency virus (HIV)-1 is transmitted between individuals via sexual intercourse or via blood products. To date there are 38 million people living with chronic HIV infection and around 1.5 million yearly acquire a new infection. LÄS MER