Sökning: "Purkinje cells"

Visar resultat 6 - 10 av 22 avhandlingar innehållade orden Purkinje cells.

  1. 6. Stem cells in inflammation and regeneration : focusing on animal models of multiple sclerosis and spinal cord injury

    Författare :Sreenivasa Raghavan Sankavaram; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The main objective of regenerative medicine is to replace or restore injured cells and tissues in the body. Stem cells are identified playing a key role in the regeneration but action of inflammatory mediators in disease is not well understood. LÄS MER

  3. 7. Identification of Unique Hematopoietic Stem Cell Properties

    Författare :Jens Nygren; Lunds universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Cardiovascular system; Hematologi; extracellulära vätskor; Haematology; extracellular fluids; cell cycle; fusion; transdifferentiation; plasticity; Medicine human and vertebrates ; Medicin människa och djur ; quiescence; hematopoietic stem cell; self-renewal;

    Sammanfattning : Hematopoietic stem cells (HSC) are sufficient and required for life long production of all blood cell lineages. Steady state HSCs are largely quiescent and we demonstrate that the kinetics of HSC cell cycling are slower compared to more committed progenitor cells also during expansion and self-renewal ex vivo and in physiological conditions. LÄS MER

  4. 8. PDGF in cerebellar development and tumorigenesis

    Författare :Johanna Andræ; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; cerebellum; medulloblastoma; PDGF; GFAP; transgenic mice; Genetik; Clinical genetics; Klinisk genetik; Pathology; patologi;

    Sammanfattning : Medulloblastoma is a highly malignant cerebellar childhood tumor. As in many other brain tumors, expression of platelet-derived growth factor (PDGF) and its receptors has been shown in medulloblastoma. LÄS MER

  5. 9. Mechanism of Action of the Antiarrhythmic Agent AZD7009

    Författare :Frida Persson; Göteborgs universitet; []
    Nyckelord :atrial fibrillation; antiarrhythmic drug; IKr; IKur; Ito; IKs; IKACh; INa; ICaL; cardiac action potential; early afterdepolarisation;

    Sammanfattning : Atrial fibrillation (AF) is the most common tachyarrhythmia in the adult population and is a major cause of morbidity and mortality. AF can be terminated and sinus rhythm restored by prolonging the action potential duration (APD) and the refractory period. LÄS MER

  7. 10. Ischemic brain damage following transient and moderate compression of sensorimotor cortex in Sprague-Dawley and diabetic Goto-Kakizaki rats

    Författare :Jurgita Kundrotiené; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Cortical compression; cerebral ischemia; neuroprotection; hyperglycemia; GotoKakizaki rats.;

    Sammanfattning : Several animal models have been developed to facilitate the investigation of biochemical, physiological, and neurological events after cerebral ischemia. In this study we present a new animal model which reliably describes morphological changes and neurological deficits produced by mild to moderate brain ischemia and which can be used to identify novel, potentially useful, neuroprotective agents. LÄS MER