Sökning: "transdifferentiation"

Visar resultat 1 - 5 av 14 avhandlingar innehållade ordet transdifferentiation.

  1. 1. Hair cell regeneration in vestibular epithelia : a study in an in vitro model

    Författare :Mimmi Werner; Diana Berggren; Andrew Forge; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Vestibular hair cell; regeneration; transdifferentiation; proliferation; utricle; rat; oto-rhino-laryngologi; Oto-Rhino-Laryngology;

    Sammanfattning : BackgroundHair cells (HCs) are the sensory receptors in both the auditory and the vestibular organs of the inner ear. Supporting cells (SCs) are non-sensory cells embracing the HCs. Injuries of the HCs by aging, acoustic trauma or ototoxic drugs (mainly aminoglycosides, e.g. LÄS MER

  3. 2. Identification of Unique Hematopoietic Stem Cell Properties

    Författare :Jens Nygren; Lunds universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Kardiovaskulära systemet; Cardiovascular system; Hematologi; extracellulära vätskor; Haematology; extracellular fluids; cell cycle; fusion; transdifferentiation; plasticity; Medicine human and vertebrates ; Medicin människa och djur ; quiescence; hematopoietic stem cell; self-renewal;

    Sammanfattning : Hematopoietic stem cells (HSC) are sufficient and required for life long production of all blood cell lineages. Steady state HSCs are largely quiescent and we demonstrate that the kinetics of HSC cell cycling are slower compared to more committed progenitor cells also during expansion and self-renewal ex vivo and in physiological conditions. LÄS MER

  4. 3. Adult Stem Cell Plasticity, Hype or Hope?

    Författare :Jalal Taneera; diabetes och endokrinologi Genomik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; pancreatic beta cell ; stem cell ; plasticity ; Medicin människa och djur ;

    Sammanfattning : Several studies have reported that bone marrow (BM)-derived stem cells have the capacity to give rise to cells of different type of tissue; an ability termed stem cell plasticity or transdifferentiation. Controversies exist as to how frequent this phenomenon is, or if it may be explained by alternative mechanisms. LÄS MER

  5. 4. Leukemia Initiation in MLL-ENL Mediated Leukemogenesis

    Författare :Amol Ugale; Avdelningen för molekylär hematologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Hematopoiesis; Luekemia; Cell of origin; Leukemia Initiation;

    Sammanfattning : In the blood system, knowledge on the regulation of hematopoietic stem cells (HSCs) and their immature progeny has provided roadmaps of differentiation. Such information can also have a value to understand the etiology of hematological cancers, since clinical heterogeneity and prognostic therapeutic outcomes have been proposed to associate with the specific developmental stage from which the transformed cells originate. LÄS MER

  7. 5. Novel markers for smooth muscle cell modulation in vascular injury and disease

    Författare :Urszula Rykaczewska; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Smooth muscle cells (SMCs) are major constituents of the vascular wall, indispensable for basic physiological functions of a healthy vessel, such as regulating vascular tone and blood pressure, but also critical during disease development. With remarkable plasticity, SMCs act as early responders to vessel wall injury, where by activating molecular mechanisms, including phenotypic modulation and transdifferentiation, they counteract detrimental stimuli and aim to restore vascular homeostasis. LÄS MER