Avancerad sökning

Hittade 3 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Nanoparticle-based capillary electrochromatography

    Författare :Peter Spégel; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Teknik; Technological sciences; Analytisk kemi; Analytical chemistry; Nanoparticles; Molecularly imprinted polymers; Capillary electrochromatography;

    Sammanfattning : This thesis concerns a highly efficient nanoparticle-based capillary electrochromatography separation technique and its coupling with mass spectrometric detection. From chromatographic theory, it is well known that the separation efficiency increases with decreasing particle size. LÄS MER

  3. 2. Integrating multi-omics for type 2 diabetes : Data science and big data towards personalized medicine

    Författare :Klev Diamanti; Jan Komorowski; Claes Wadelius; Manfred Grabherr; Peter Spégel; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; type 2 diabetes; multi-omics; genomics; metabolomics; data science; machine learning; personalized medicine; Bioinformatics; Bioinformatik;

    Sammanfattning : Type 2 diabetes (T2D) is a complex metabolic disease characterized by multi-tissue insulin resistance and failure of the pancreatic β-cells to secrete sufficient amounts of insulin. Cells recruit transcription factors (TF) to specific genomic loci to regulate gene expression that consequently affects the protein and metabolite abundancies. LÄS MER

  4. 3. Diagnosis of acute and chronic enteric fever using metabolomics

    Författare :Elin Näsström; Henrik Antti; Anders Johansson; Peter Spégel; Umeå universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Enteric fever; Salmonella; chronic carriers; metabolomics; diagnosis; biomarkers; multivariate data analysis; GCxGC-MS; GC-MS; LC-MS;

    Sammanfattning : Enteric (or typhoid) fever is a systemic infection mainly caused by Salmonella Typhi and Salmonella Paratyphi A. The disease is common in areas with poor water quality and insufficient sanitation. Humans are the only reservoir for transmission of the disease. LÄS MER