Sökning: "PAX2"

Hittade 4 avhandlingar innehållade ordet PAX2.

  1. 1. Predicting Prognosis and Tamoxifen Response in Breast Cancer. With a special focus on contralateral breast cancer

    Författare :Sara Alkner; Bröstcancer-genetik; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; prognosis; treatment prediction; endocrine treatment; tamoxifen; coactivator; AIB1; PAX2; SRC; contralateral breast cancer; premenopausal; randomized trial; mode of detection; mammography.;

    Sammanfattning : One of the great challenges in breast cancer treatment today is to customize adjuvant treatment to each patient’s individual needs. To do this it is necessary to learn more about the prognostic and treatment predictive factors that determine the risk of relapse and response to a certain mode of treatment. LÄS MER

  3. 2. Characterization of Retinal Progenitor Cells : Focus on Proliferation and the GABAA Receptor System

    Författare :Henrik Ring; Finn Hallböök; Per Söderberg; Andras Simon; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Regeneration; Proliferation; Neurotransmitters; Müller cells; Differentiation; Retinal repair; Neurogenesis; Medical Science; Medicinsk vetenskap;

    Sammanfattning : One strategy to repair an injured or degenerated retina is to stimulate the replacement of damaged or dead neurons with cells derived from endogenous stem- or progenitor cells. A successful strategy requires knowledge about how the proliferation and differentiation of the endogenous cells are regulated. LÄS MER

  4. 3. Functional Aspects of Peripheral and Spinal Cord Neurons Involved in Itch and Pain

    Författare :Bejan Aresh; Malin Lagerström; Klas Kullander; Martin Schmelz; Uppsala universitet; []
    Nyckelord :mGluR7; anaphylaxis; Grpr; Penk; Pdyn; Cre line; BAC cloning; spinal cord; transgenic line; Medicinsk vetenskap; Medical Science;

    Sammanfattning : We have investigated the role of the metabotropic glutamate receptor 7 (mGluR7) and the gastrin releasing peptide receptor (Grpr) population that are involved at different levels of itch transmission. We found that mGuR7 deficient mice displayed an anaphylaxis-like behavior when provoked with histamine. LÄS MER

  5. 4. Na,K-ATPase as signaling transducer

    Författare :Juan Li; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : It is now generally agreed that Na,K-ATPase (NKA), in addition to its role in the maintenance of Na+ and K+ gradients across the cell membrane, is a signal transducer. Our group has identified a novel signaling pathway where NKA interact with IP3R to form a signaling microdomain. LÄS MER