Sökning: "Notch"

Visar resultat 21 - 25 av 189 avhandlingar innehållade ordet Notch.

  1. 21. The life and death of the notch intracellular domain

    Författare :Camilla Öberg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The Notch signaling pathway is an evolutionarily conserved way of communicating between cells that contact each other. Notch is a single-transmembrane spanning receptor that interacts with single-transmembrane spanning ligands on adjacent cells. In vertebrates the Notch family of receptor consists of four members: Notch1 to Notch4. LÄS MER

  3. 22. Dysregulated Notch signaling in breast cancer and liver disease

    Författare :Indira Chivukula; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The evolutionarily conserved Notch signaling pathway regulates crucial aspects of development and tissue homeostasis. This thesis contributes research towards understanding a role of non-canonical Notch signaling in the tumor-stroma interaction of breast cancer, provides a bioinformatics-based technology to study these interactions, and proposes a novel mouse model of the liver disease in Alagille syndrome. LÄS MER

  4. 23. Notch sensitivity and failure of glass mat reinforced polypropylene

    Författare :Johan Lindhagen; Luleå tekniska universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Polymera konstruktionsmaterial; Polymeric Composite Materials;

    Sammanfattning : .... LÄS MER

  5. 24. The ins and outs of notch ligands and downstream events

    Författare :Emil Hansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Signaling through the Notch receptor constitutes an evolutionarily conserved pathway important for embryonic development of many organs, including the central nervous system and vasculature, in multicellular animals. The Notch receptor is a transmembrane protein that, upon binding of ligands presented on neighboring cells, undergoes proteolytic processing events leading to the release of the Notch intracellular domain (ICD). LÄS MER

  7. 25. Machinability variations in alloy 718 turbine components

    Författare :Pajazit Avdovic; Chalmers tekniska högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; variation in tool; hardness; Machining; flank wear; notch wear; alloy 718; grain size; instability; variation in material;

    Sammanfattning : Machinability Variations in Alloy 718 Turbine Components PAJAZIT AVDOVIC Department of Materials and Manufacturing TechnologyChalmers University of Technology AbstractAlloy 718 has a reputation for being very troublesome during the cutting process. It was suspected that this material was too hard and having too fine grain size and that these characteristics caused damage to cutting tools during processing. LÄS MER