Sökning: "NMDA receptor"

Visar resultat 21 - 25 av 126 avhandlingar innehållade orden NMDA receptor.

  1. 21. Regulation of NMDA receptor properties by amino acids and cations : a biochemical and electrophysiological study

    Författare :Yun Liu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :NMDA receptor; Glutamate; Glycine; [3H]MK-801 binding; Magnesium; Calcium; Tris; Potassium; Sodium; Proton; Xenopus oocytes; Spinal cord; Cerebral cortex; Receptor binding; Electrophysiology;

    Sammanfattning : NMDA receptors are glutamate-regulated ion channels that are permeable to Ca2+, Na+ and K+ and are sensitive to voltage-dependent Mg2+-block. To investigate the modulatory effects of amino acids and cations on NMDA receptors and the possible regional differences in the pharmacology of NMDA receptors, I used mainly two techniques in this thesis: electrophysiological analysis of expressed NMDA receptors in Xenopusoocytes and biochemical receptor binding using [3H]MK-801 in membrane preparations from the rat cerebral cortex and spinal cord. LÄS MER

  3. 22. Genetic factors and the role of the NMDA receptor in pain modulation and the effect of opioids

    Författare :Aida Plesan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :pain; NMDA-receptor antagonists; genetic difference; rat strain; opioids; methadone; morphine tolerance; neuropathic pain;

    Sammanfattning : Pain perception and the response to opioid analgesics are determined by a number of factors, among which genetic variability and the activation of the NMDA-receptor for glutamate play an important role. The effects of two clinically available NMDA-receptor antagonists, ketamine (KET) and dextromethorphan (DEX), were evaluated on an animal model of acute nociception, the hot plate test, and on human experimental acute ischemic pain. LÄS MER

  4. 23. Plasticity of the dopamine1 receptor and its signaling pathway

    Författare :Maria Sol Kruse; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Dopamine; D1R; trafficking; signaling pathway; NMDA;

    Sammanfattning : Dopamine 1 receptor (D1R) belongs to the G protein coupled receptor superfamily with seven transmembrane domains. Previous studies from our laboratory showed that D1R availability in the plasma membrane of renal epithelial cells is dynamically regulated by the dopaminergic tonus. Here, we *examined the availability of D1R in the brain. LÄS MER

  5. 24. On the role of NMDA receptor subunits in the acute and chronic effects of nicotine

    Författare :Alexander Kosowski; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :PCR; microdialysis; Wistar;

    Sammanfattning : Nicotine is considered the main dependence-producing constituent in tobacco products. In analogy with other drugs of abuse, nicotine enhances dopamine (DA) neurotransmission within the mesocorticolimbic DA system. LÄS MER

  7. 25. Influenza A virus infection and NMDA receptor function : a behavioral and molecular study of relevance for schizophrenia

    Författare :Simret Beraki; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Schizophrenia; Influenza A virus; NMDA receptor; glutamate; cognition; learning; memory; hippocampus; water maze; mice; emotional; social interaction; gene expression; brain; behavior; phencyclidine; elevated plus-maze;

    Sammanfattning : Schizophrenia is a neuropsychiatric disorder characterized by positive and negative symptoms, as well as cognitive dysfunctions. There is no single cause of schizophrenia, instead complex combinations of genetic and environmental factors may contribute to the disorder, including exposure to viral infections or other environmental insults during early life. LÄS MER