Sökning: "NIDDM"

Visar resultat 16 - 20 av 22 avhandlingar innehållade ordet NIDDM.

1. 16. Islet insulin secretory patterns in diabetes and the role of UCP2

   Författare :Jian-Man Lin; Valdemar Grill; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell biology; type 1 diabetes; type 2 diabetes; NOD; GK; congenes; KKAy; human; islet; glucose; insulin release; oscillation; frequency; amplitude; oxidation; respiration; UCP2; western blot; Cellbiologi; Cell biology; Cellbiologi; medicinsk cellbiologi; Medical Cell Biology;

   Sammanfattning : During development of type 1 and type 2 diabetes plasma insulin patterns are altered. Since the islet insulin release pattern has been implicated in this development, insulin secretion from single islets was studied and linked to the islet protein levels of uncoupling protein-2 (UCP2). LÄS MER

3. 17. Islet amyloid polypeptide : Perspectives on the storage and plasma concentration of islet amyloid polypeptide (IAPP) in rodent models of obesity and non-insulin-dependent diabetes mellitus and aspects of amyloidogenesis andelimination of IAPP

   Författare :Arnold Leckström; Sture Falkmer; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : The present study was aimed to investigate plasma concentrations and pancreatic storage of IAPP in relation to that of insulin in four different animal models with hyperglycemia, hyperinsulinemia, obesity and/or NIDDM. The NMRI mice fed a high-fat diet for six months, the Psammomys on high-energy (HE) diet and the genetically obese (ob/ob) mice studied for one year all revealed significantly elevated plasma IAPP concentrations, while the IAPP levels were unchanged in the spontaneously diabetic GK rats during a glucose tolerance test. LÄS MER

4. 18. Nitric oxide (NO) and carbon monoxide (CO): A novel class of messenger molecules regulating insulin and glucagon secretion

   Författare :Ragnar Henningsson; Institutionen för experimentell medicinsk vetenskap; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; carbon monoxide CO ; nitric oxide NO ; Nitric oxide synthase NOS ; Insulin and glucagon secretion; cyclic nucleotides; Endocrinology; secreting systems; diabetology; Endokrinologi; sekretion; diabetologi; Heme oxygenase HO ;

   Sammanfattning : During the last decade it has been shown that nitric oxide (NO) and carbon monoxide (CO) are produced in our own body, and that they constitute a novel class of messenger molecules. In 1992 a constitutive NO-producing NO-synthase (cNOS) was found in the islets of Langerhans, and in 1997 we could show for the first time that the islets also contained a CO-producing constitutive heme oxygenase (HO-2). LÄS MER

5. 19. Intrapulmonary insulin : Experimental and clinical studies

   Författare :Johan H. Jendle; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : After intrapulmonary insulin administration was first reported in 1925, the development of highly efficient nebulisers has once again made this area interesting. Therefore, the distribution and retention of aerosol produced by a new jet nebuliser was evaluated in an animal model. LÄS MER

7. 20. Non-invasive assessment of dynamic properties in human arteries : with special reference to gestation and diabetes

   Författare :Jie Hu; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Acetylcholine; Adolescents; Aorta; Diameter waveforms; Diameter pulse waves; Echo tracking system; Fetal behavioural state; Fetal breathing movements; Gestational diabetes mellitus; Impending birth; Insulin-dependent diabetes mellitus; Laser Doppler; Microcirculation; Pregnancy; Pulse wave velocity; Vascular endothelium; Vascular stiffness; Ultrasound;

   Sammanfattning : Background: The important role played by the intrinsic properties of central arteries in cardiovascular physiology and pathology has been increasingly recognised. Several circulatory disorders are associated with increased arterial stiffness. LÄS MER