Sökning: "NFκB"

Visar resultat 11 - 15 av 39 avhandlingar innehållade ordet NFκB.

  1. 11. Inflammation and Intestinal Homeostasis-Associated Genes in Colorectal Cancer

    Författare :Jonas Ungerbäck; Peter Söderkvist; Martin Hallbeck; Kari Hemminki; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Colorectal cancer (CRC) is a global ‘killer’ and every year more than 1.2 million new individuals are affected and approximately 600 000 succumb to the disorder. Several mechanisms such as inactivation of tumor suppressor genes, activation of oncogenes and dysregulation of cell fate determinating pathways e.g. LÄS MER

  3. 12. DNA-Mediated Detection and Profiling of Protein Complexes

    Författare :Maria Hammond; Ulf Landegren; Masood Kamali-Moghaddam; Christof Niemeyer; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Proximity ligation assay; Protein complexes; Protein interactions; Biomarkers; Prions; Antibodies; Medicinsk vetenskap; Medical Science;

    Sammanfattning : Proteins are the effector molecules of life. They are encoded in DNA that is inherited from generation to generation, but most cellular functions are executed by proteins. Proteins rarely act on their own – most actions are carried out through an interplay of tens of proteins and other biomolecules. LÄS MER

  4. 13. Estrogen receptor beta transcriptional regulation: A potential mechanism for colon cancer prevention

    Författare :Rajitha Indukuri; Cecilia Williams; Jason Carroll; KTH; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medical Technology; Medicinsk teknologi;

    Sammanfattning : Colorectal cancer (CRC) is the third leading cause of death from cancer in both men andwomen in the Western world. Improved screening efforts, surveillance, and treatment havereduced CRC mortality in older patients. However, the incidence is increasing in young adults,even in the absence of CRC family history. LÄS MER

  5. 14. Activation of epithelial signal transduction pathways, cytokine production and airway inflammation following diesel exhaust exposure

    Författare :Jamshid Pourazar; Thomas Sandström; Anders Blomberg; Anders Lindén; Umeå universitet; []
    Nyckelord :MEDICINE; MEDICIN;

    Sammanfattning : Adverse health effects of ambient air pollution are well recognised and include increased morbidity and mortality in respiratory and cardiovascular diseases. Diesel engines are major contributors to ambient particulate matter pollution and diesel particles have been shown to have strong toxicological and oxidative properties. LÄS MER

  7. 15. Role and mechanism of estrogen receptor beta in the physiology of the ovary and colon

    Författare :Madeleine Birgersson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Estrogen regulates a variety of important physiological functions in both males and females, where the regulation of female reproduction and the development of sexual organs are typical examples. The effects of estrogen are predominantly exerted via signaling through the two nuclear receptors estrogen receptor α (ERα) and β (ERβ), or the membrane G protein-coupled estrogen receptor 1 (GPER1). LÄS MER