Sökning: "Modified LDL"

Visar resultat 11 - 15 av 30 avhandlingar innehållade orden Modified LDL.

  1. 11. Circulating immune complexes in atherosclerotic vascular disease

    Författare :Awder Mustafa; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :circulating immune complexes; autoantibodies; lipoproteins; cardiolipin; oxidized LDL; atherosclerosis; myocardial infarction; food proteins; complement factor C4.;

    Sammanfattning : We have investigated the association of the humoral immune factors circulating immune complexes (CICs) and autoantibodies against cardiolipin (aCL) and oxidatively modified LDL (oxLDL) to atherosclerotic vascular diseases. In a prospective nested case-control study, in which healthy 50-year-old men were followed for 20 years, the prevalence of elevated CICs and the concentration of CICs were higher in men who developed myocardial infarction. LÄS MER

  3. 12. Immune mechanisms in atherosclerosis

    Författare :Ejaz Ahmed; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :atherosclerosis; diabetes; stroke; rheumatoid arthritis; autoantibodies; anticardiolipin; oxidized LDL; hypercholesterolernia; IFN-gamma TNF-alpha IL-1beta IL-1Ra.;

    Sammanfattning : Atherosclerosis is a multifactorial chronic inflammatory disorder. Humoral immune factors as anticardiolipin antibodies (aCL), anti-oxLDL antibodies, circulating immune complexes (CICs), and proinflammatory cytokines such as IFN-gamma, TNF-alpha and EL-1beta have been implicated in atherogenesis. LÄS MER

  4. 13. Tumor necrosis factor-a in atherosclerosis

    Författare :Stefan Jovinge; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :atherosclerosis; oxidized low-density lipoprotein; monocytes; tumor necrosis factor-a; cytokinesis; ets-l; matrix metalloproteinases; apoptosis; glucose metabolism; insulin resistance; myocardial infarction;

    Sammanfattning : The presence of inflammatory cells is prominent at all phases of the atherosclerotic process leaving no doubt that the inflammation is of central importance in atherosclerosis. The recruitment of inflammatory cells into the vessel wall is therefore a key event in early lesion formation. LÄS MER

  5. 14. Protective Immunity in Atherosclerosis

    Författare :Maria Wigren; Kardiovaskulär forskning - immunitet och ateroskleros; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AtherosclerosisVaccineInflammationT cellsregulatory T cells;

    Sammanfattning : The immune system is a promising target for novel therapies that are aiming at reducing cardiovascular diseases. Autoimmune responses against modified low density lipoprotein (LDL) are believed to promote development of atherosclerosis. Proinflammatory immune responses can be counterbalanced by immunosuppressive regulatory T cells (Tregs). LÄS MER

  7. 15. Cardiovascular risk factors, diet and the metabolic syndrome

    Författare :Per Sjögren; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The clustering of metabolic disturbances, referred to as the metabolic syndrome, is today at the centre of attention. The rationale for this focus is that the prevalence of the metabolic syndrome is increasing globally with subsequent increased risk for cardiovascular complications. LÄS MER