Sökning: "Macrocyclic compounds"

Visar resultat 1 - 5 av 24 avhandlingar innehållade orden Macrocyclic compounds.

1. 1. A Microcalorimetric Study of Macrocyclic Complexes in Aqueous Solution

   Författare :Magnus Stödeman; Fysikalisk kemi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Chemistry; Aqueous Solution; Calixarene; Cyclodextrin; Vaporization; Macrocyclic compounds; Microcalorimetry; Kemi;

   Sammanfattning : The present work involves a microcalorimetric characterization of the interactions among macrocyclic compounds and aliphatic molecules in aqueous solution. The macrocyclic compounds used in the study are a-,b- and g-cyclodextrin and 25,26,27,28-tetrahydroxycalix[4]arene-5,11,17,23- tetrasulphonate. LÄS MER

3. 2. Synthesis and Studies of NADH Models: Stereoselective Reductions and Host-Guest Properties

   Författare :Ulrik Gran; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; synthesis; NADH model; host-guest complex; stereoselective reductions; macrocyclic; reducing agent;

   Sammanfattning : The aim of the project has been to synthesise macrocyclic NADH models and to study them as reducing agents and hosts. Three types of macrocyclic NADH models have been synthesised. They consist of the same subunits; a chiral unit, a nicotinamide unit and an aromatic spacer. LÄS MER

4. 3. Discovery of Novel Macrocyclic Ligands for Difficult Targets : Applications to Natural Product Derived Keap1 Inhibitors

   Författare :Fabio Begnini; Jan Kihlberg; Anders Bach; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Macrocycles; Keap1-Nrf2; Protein-protein interactions; Natural products;

   Sammanfattning : The development of small-molecule ligands for biological targets that possess large, featureless or highly polar binding sites is a challenging task. This thesis is focused on a novel lead generation strategy to identify macrocyclic ligands for difficult-to-drug targets, as well as on the relationship between cell permeability and the conformations of macrocycles. LÄS MER

5. 4. Cytotoxic Compounds of Plant Origin – Biological and Chemical Diversity

   Författare :Petra Lindholm; Anders Backlund; Lars Bohlin; Kristín Ingólfsdóttir; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmacognosy; pharmacognosy; cytotoxicity; antitumour; Nuphar alkaloid; cyclotide; thionin; cardiac glycoside; Farmakognosi; Pharmacognosy; Farmakognosi;

   Sammanfattning : The development of resistance by tumour cells to chemotherapeutic agents is a major problem in cancer treatments. One way to counter this is to find compounds with cytotoxic mechanisms other than those of drugs in clinical use today. LÄS MER

7. 5. Design and Synthesis of Hepatitis C Virus NS3 Protease Inhibitors Incorporating a P2 Cyclopentane-Derived Scaffold

   Författare :Marcus Bäck; Anja Sandström; Linköpings universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; HCV; NS3 protease; Proline mimic; Cyclopentane-derived scaffold; Linear inhibitors; Macrocyclic inhibitors; Organic synthesis; Organisk syntes;

   Sammanfattning : This thesis describes the design, synthesis and structure-activity relationships analysis of potential inhibitors targeting the hepatitis C virus (HCV) NS3 protease. Also discussed is the disease caused by HCV infection and the class of enzymes known as proteases. LÄS MER