Sökning: "Leif Andersson"

Visar resultat 11 - 15 av 32 avhandlingar innehållade orden Leif Andersson.

  1. 11. Genetic Analysis of Fat Metabolism in Domestic Pigs and their Wild Ancestor

    Författare :Frida Berg; Leif Andersson; Maria Moller; Stefan Marklund; Sigbjörn Lien; Uppsala universitet; []
    Nyckelord :Genetics; Pig; Quantitative Trait Locus; Fat deposition; FAT1; Linkage map; RH map; Comparative map; Backcross; Identical by Descent mapping; Brown adipose tissue; UCP1; Genetik;

    Sammanfattning : The domestication of the pig began about 9 000 years ago and many of the existing domestic breeds have been selected for phenotypic traits like lean meat and fast growth. Domestic pigs are phenotypically very different from the ancestral wild boar that has adapted to survive in their natural environment. LÄS MER

  3. 12. Meiotic Recombination in Human and Dog : Targets, Consequences and Implications for Genome Evolution

    Författare :Jonas Berglund; Matthew Webster; Kerstin Lindblad-Toh; Leif Andersson; Nadia Singh; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; recombination; biased gene conversion; CpG island; copy number variation; substitutions; methylation; Bioinformatics; Bioinformatik; Biology with specialization in Evolutionary Genetics; Biologi med inriktning mot evolutionär genetik; Biologi med inriktning mot molekylär evolution; Biology with specialization in Molecular Evolution; Molekylär genetik; Molecular Genetics;

    Sammanfattning : Understanding the mechanism of recombination has important implications for genome evolution and genomic variability. The work presented in this thesis studies the properties of recombination by investigating the effects it has on genome evolution in humans and dogs. LÄS MER

  4. 13. A sub-phenotype approach to dissect the genetic control of murine type 1 diabetes

    Författare :Marie-Louise Bergman; Leif Andersson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : The non-obese diabetic (NOD) mouse is a model for human type 1 diabetes (T1D). The disease in the NOD mouse is polygenic and multifactorial and so far at least 20 insulin dependent diabetes (Idd) susceptibility loci have been identified. However, no etiological mutations have been definitely ascribed to the Idd loci. LÄS MER

  5. 14. Genetic and Genomic Studies in Chicken : Assigning Function to Vertebrate Genes

    Författare :Jonas Eriksson; Leif Andersson; Greger Larson; Göran Hjälm; Tosso Leeb; Uppsala universitet; []
    Nyckelord :Chicken; BCO2; TSHR; COMTD1; Phenotypic variation; Domestication; Selective sweeps; Pigmentation; Molekylär genetik; Molecular Genetics;

    Sammanfattning : A major challenge in the post-genomic era is to understand how genome sequence variants (genotype) give rise to the enormous diversity observed in terms of morphology, physiology and behavior (phenotype) among living organisms. Domestic animals—with their tremendous phenotypic variation—are excellent model organisms for determining the relationships between genotype and phenotype. LÄS MER

  7. 15. Exploring the Realm of Gene Expression Differences Between White Leghorn and Red Junglefowl Chickens

    Författare :Carolyn Fitzsimmons; Leif Andersson; Finn Hallböök; Dave Burt; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Molecular genetics; chicken; gene expression; microarray; polymorphism; Genetik; Genetics; Genetik;

    Sammanfattning : In this thesis we attempted to elicit patterns of gene expression that influence phenotype, and that may also have been altered by thousands of years of domestication and selection, between red junglefowl and White Leghorn chickens. Red junglefowl are the wild ancestor to all domesticated chickens, and poultry in general are highly valued as a research animal and food resource. LÄS MER