Sökning: "TSHR"

Visar resultat 1 - 5 av 12 avhandlingar innehållade ordet TSHR.

1. 1. Genetic and Genomic Studies in Chicken : Assigning Function to Vertebrate Genes

   Författare :Jonas Eriksson; Leif Andersson; Greger Larson; Göran Hjälm; Tosso Leeb; Uppsala universitet; []
   Nyckelord :Chicken; BCO2; TSHR; COMTD1; Phenotypic variation; Domestication; Selective sweeps; Pigmentation; Molekylär genetik; Molecular Genetics;

   Sammanfattning : A major challenge in the post-genomic era is to understand how genome sequence variants (genotype) give rise to the enormous diversity observed in terms of morphology, physiology and behavior (phenotype) among living organisms. Domestic animals—with their tremendous phenotypic variation—are excellent model organisms for determining the relationships between genotype and phenotype. LÄS MER

3. 2. The genetic basis for adaptation in natural populations

   Författare :Sangeet Lamichhaney; Leif Andersson; Carl-Johan Rubin; Alvaro Martinez Barrio; Henrik Kaessmann; Uppsala universitet; []
   Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; Adaptive evolution; Atlantic herring; ecological adaptation; seasonal reproduction; TSHR; Darwin’s finches; natural selection; beak; ALX1; HMGA2; ruff; lek; inversion; HSD17B2; MC1R;

   Sammanfattning : Many previous studies in evolutionary genetics have been based on few model organisms that can be reared at ease in the laboratory. In contrast, genetic studies of non-model, natural populations are desirable as they provide a wider range of adaptive phenotypes throughout evolutionary timescales and allow a more realistic understanding of how natural selection drives adaptive evolution. LÄS MER

4. 3. Exploring genetic diversity in natural and domestic populations through next generation sequencing

   Författare :Nima Rafati; Leif Andersson; Carl-Johan Rubin; Alvaro Martinez Bario; Craig Primmer; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Ecological adaptation; seasonal reproduction; Atlantic herring; domestication; speciation; rabbit; skeletal atavism; Shetland ponies; NGS; SMRT sequencing; genome; transcriptome; assembly; structural variation; genetic diversity; HCE; TSHR; SHOX; CRLF2;

   Sammanfattning : Studying genetic diversity in natural and domestic populations is of major importance in evolutionary biology. The recent advent of next generation sequencing (NGS) technologies has dramatically changed the scope of these studies, enabling researchers to study genetic diversity in a whole-genome context. LÄS MER

5. 4. Presence of extrathyroidal TSH-receptor, with special reference to its role in neonatal regulation of lipolysis

   Författare :Annika Janson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :adaptation; adipocytes; Graves disease; growth hormone; human; hyper thyroidism; infant; insulin; metabolism; TSHR stimulating antibodies; thyrotropin; TSH.;

   Sammanfattning : At birth, the newborn child must utilize stored energy until lactation is established. The main source of energy is fat - that is, triglycerides stored in the white adipose tissue. This study deals with hormonal regulation of lipolysis in the neonatal period. LÄS MER

7. 5. Genetic and functional studies on the thyroid hormone axis

   Författare :Abdelaziz Elgadi; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : This thesis has two main parts. The first is based on the first three papers with a focus on understanding the etiology and pathogenesis of thyroid malfunction and its effects on different organs. LÄS MER