Sökning: "Imidazo[1"

Hittade 3 avhandlingar innehållade ordet Imidazo[1.

1. 1. Hit Identification and Hit Expansion in Antituberculosis Drug Discovery : Design and Synthesis of Glutamine Synthetase and 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase Inhibitors

   Författare :Anneli Nordqvist; Anders Karlén; Mats Larhed; Anders Hallberg; Anna Linusson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Tuberculosis; Glutamine synthetase; Imidazo[1; 2-a]pyridine analogues; Focused hierarchical design of experiments; DXR; Fosmidomycin analogues; 1-Deoxy-D-xylulose-5-phosphate reductoisomerase; Cinnamaldehydes; Oxidative Heck reaction; Pharmaceutical chemistry; Läkemedelskemi; Medicinal Chemistry; Läkemedelskemi;

   Sammanfattning : Since the discovery of Mycobacterium tuberculosis (Mtb) as the bacterial agent causing tuberculosis, the permanent eradication of this disease has proven challenging. Although a number of drugs exist for the treatment of tuberculosis, 1.7 million people still die every year from this infection. LÄS MER

3. 2. Inhibitors Targeting Insulin-Regulated Aminopeptidase (IRAP) : Identification, Synthesis and Evaluation

   Författare :Karin Engen; Mats Larhed; Mikael Elofsson; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; compound screening; insulin-regulated aminopeptidase; IRAP; inhibitors; cognitive disorders; spiro-oxindole; quinazolinone; imidazopyridine; medicinal chemistry; structure-activity relationship; microwave heating; Medicinal Chemistry; Läkemedelskemi;

   Sammanfattning : Insulin-regulated aminopeptidase (IRAP) has emerged as a potential new therapeutic target for treatment of cognitive disorders. Inhibition of the enzymatic activity facilitates cognition in rodents. LÄS MER

4. 3. Design and Synthesis of Novel Glutamine Synthetase Inhibitors and Development of Palladium(0)-Catalyzed Aminocarbonylation

   Författare :Olof Lagerlund; Mats Larhed; Anders Karlén; Anders Hallberg; Michael Begtrup; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; Farmaceutisk kemi; Medicinal Chemistry; läkemedelskemi;

   Sammanfattning : Tuberculosis (TB) is a major infectious disease, killing about 2 million people annually throughout the world. Today's TB treatment is a lengthy procedure involving a combination of antibiotics. No new TB drug has been introduced onto the market in the past 40 years, and the emergence of multi- and extensively drug-resistant TB calls for new drugs. LÄS MER